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Alanyl-glutamine attenuates 5-fluorouracil-induced intestinal mucositis in apol...

Araújo, C.V.; Lazzarotto, Cícera Regina; Aquino, Cristhyane Costa de; Figueiredo, Italo L.; Costa, Tiê Bezerra; Alves, L. A. de Oliveira

Apolipoprotein E (APOE=gene, apoE=protein) is a known factor regulating the inflammatory response that may have regenerative effects during tissue recovery from injury. We investigated whether apoE deficiency reduces the healing effect of alanyl-glutamine (Ala-Gln) treatment, a recognized gut-trophic nutrient, during tissue recovery after 5-FU-induced intestinal mucositis. APOE-knockout (APOE-/-) and wild-type ...

Date: 2016   |   Origin: Oasisbr

Genetic profile of two isolates of Trypanosoma evansi from southern Brazil with...

Duarte, Daniel Pereira; Komati, Larissa Kaori Oide; Simiano Tavares, Kaio César; Lazzarotto, Cícera Regina; Ferreira, Éden Ramalho de Araújo

Trypanosoma evansi is the most widespread pathogenic trypanosome, due to its ability to be mechanically transmitted by hematophagous flies. Some studies have shown that T. evansi has a high genetic homology among populations around the world, but they have not described the relationships among infection patterns in the host. In this study, we used molecular techniques to determine the genetic variability of two...

Date: 2014   |   Origin: Oasisbr

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