42 documents found, page 1 of 5
Marine cyanobacteria isolated from the portuguese coast as a source of bioactiv...
Martins, Rosário; Costa-Rodrigues, João; Barros, Piedade; Costa, Margarida; Leão, PedroAs cianobactérias marinhas constituem uma fonte promissora de compostos com potencial antitumoral. Nos últimos anos, um arsenal de compostos tem sido revelado, alargando a gama de novos compostos ou estruturas de base ao desenvolvimento de novas drogas. Neste projeto tivemos como objetivo avaliar o potencial de cianobactérias da coleção LEGE-CC como fonte de compostos antitumorais. Foi também nosso objetivo ava...
Metronidazole delivery nanosystem able to reduce the pathogenicity of bacteria ...
Oliveira, Ana; Araújo, Ana; Rodrigues, Luísa C.; Silva, Catarina S.; Reis, R. L.; Neves, N. M.; Leão, Pedro; Martins, AlbinoMetronidazole (MTZ) is a drug potentially used for the treatment of intestinal infections, namely, the ones caused by colorectal surgery. The traditional routes of administration decrease its local effectiveness and present off-site effects. To circumvent such limitations, herein a drug delivery system (DDS) based on MTZ-loaded nanoparticles (NPs) immobilized at the surface of electrospun fibrous meshes is prop...
Recent approaches on signal transduction and transmission in acupuncture: a bio...
Gomes, Lígia Rebelo; Leão, PedroAcupuncture is one of the areas among the alternative therapies that arouses high curiosity in the biomedical scientific community. It is particular popular for treatment of chronic diseases and addictions. However, contrasting with its evidence based effectiveness, the lack of a reasonable explanations for its mode of action divides that scientific community. Difficulties also arise to those responsible for pr...
Norhierridin B, a New Hierridin B-Based Hydroquinone with Improved Antiprolifer...
Brandão, Pedro; Moreira, Joana; Almeida, Joana; Nazareth, Nair; Sampaio-Dias, Ivo E.; Vasconcelos, Vítor; Martins, Rosario; Leão, Pedro; Pinto, MadalenaHierridin B (6), a methylated hydroquinone isolated from the marine picocyanobacterium Cyanobium sp. LEGE 06113, moderately inhibited the growth of colon adenocarcinoma HT-29 cells. Aiming to improve the potential antitumor activity of this natural product, the demethylated analogue, norhierridin B (10), as well as its structurally-related quinone (9), were synthesized and evaluated for their growth inhibitory ...
THORACOSCOPIC ENUCLEATION OF A SUBMUCOSAL ESOPHAGEAL LIPOMA
Sousa, Maria; Cristino, Humberto; Reis, Mário; Leão, PedroAims: case-report of a toracoscopic enucleation of esophageal lipoma. Lipomas of the gastrointestinal tract are rare, and those of the esophagus are extremely rare. Surgical enucleation is indicated in case of symptoms or an unclear diagnosis. Toracoscopic enucleation has been developed as a preferred approach for most lesions in recent years. Methods: clinical data collected from computerized records of the pa...
The correlation between serum vascular endothelial growth factor (VEGF) and tum...
Goulart, André; Ferreira, Carla; Rodrigues, Ana; Coimbra, Barbara; Sousa, Nuno; Leão, PedroDespite plasma biomarkers offering a number of advantages over tissue-based markers, the relationship between serum vascular endothelial growth factor (VEGF) and VEGF receptor (VEGF-R) tumor expression in colorectal cancer (CRC) is still unclear. This study was designed to establish the relationship between the concentration of serum VEGF and tumor VEGF-R expression in patients with CRC.
Influence of visceral fat in the outcomes of colorectal cancer
Goulart, André; Malheiro, Nuno; Rios, Hugo; Sousa, Nuno; Leão, PedroAim: To determine the relationship of visceral fat (VF) with the surgical outcome of the patients with colorectal cancer (CRC) submitted to curative surgery. Methods: Retrospective analysis of all patients submitted to CRC surgery during 3 years with a minimum of 5 years of follow-up. We assessed the length of hospital stay, complications, pathologic reports, surgical re-interventions and hospital re-admissions...
Abdominal catastrophe in crohn's disease surgery
Rios, Hugo Palma; Goulart, André; Leão, PedroPerforming surgery on patients with Crohn's disease is a true challenge due to the elevated risk of complications related to the chronic proinflammatory response. Stenosis is the leading cause of intestinal resection in these patients.
Generation of spheroids of cancer cells for screening of antitumour activity of...
Sousa, Maria Lígia; Preto, Marco; Vasconcelos, Vítor; Martins, Rosário; Linder, Stig; Leão, Pedro; Urbatzka, RalphThe use of 3D cell culture for modelling cancer research is gaining interest, and in particular for screening of bioactive compounds. In the presented work, three compounds isolated from cyanobacteria and 92 chromatographic fractions obtained from crude organic extracts of 28 cyanobacterial strains from the Portuguese coast were tested on multicellular spheroids generated from the human cell lines HCT116 (colon...
The influence of metabolic syndrome in the outcomes of colorectal cancer patients
Goulart, André; Varejão, Ana; Nogueira, Fernanda; Martins, Sandra; Mesquita-Rodrigues, António; Sousa, Nuno; Leão, PedroAims: Determine the influence of metabolic syndrome and its different components in the outcomes of colorectal cancer surgery at 30 days. Materials and methods: Prospective study that included all patients submitted to elective colorectal cancer surgery between August 2015 and August 2016 at Hospital de Braga. Clinical and laboratory parameters evaluated pre-operatively were: central obesity, blood pressure, fa...