4 documents found, page 1 of 1
A multicenter, non-interventional study to evaluate the disease activity in Mul...
Ladeira, F; Braz, L; Salgado, P; Vaz, S; Leitão, L; Félix, C; Salgado, V, et al.Abstract OBJECTIVES: Natalizumab (NTZ) is very effective for treatment of relapsing-remitting multiple sclerosis (RRMS), its use is mainly limited by safety issues. Discontinuation of NTZ is associated with recurrence of disease activity (reactivation and rebound). The best strategy for subsequent therapy and the predictive factors for recurrence in such patients are areas of active research. We aimed to evalua...
Gordon Holmes syndrome due to compound heterozygosity of two new PNPLA6 variant...
Salgado, P; Carvalho, R; Brandão, AF; Jorge, P; Ramos, C; Dias, D; Alonso, I; Magalhães, MBackground: Gordon Holmes syndrome (GHS), characterized by cerebellar ataxia and hypogonadotropic hypogonadism (HH), has been related to recessive mutations in PNPLA6 gene. Aims of the study: Describe one Portuguese family with GHS due to compound heterozygosity of two new PNPLA6 variants. Methods: Report on the clinical presentation, diagnostic and genetic workup to reach GHS diagnosis. Results: The index case...
A Multicenter, Non-Interventional Study to Evaluate the Disease Activity in Mul...
Ladeira, F; Braz, L; Salgado, P; Vaz, S; Leitão, L; Félix, C; Correia, AS; Martins da Silva, A; Salgado, V; Ferreira, F; Vale, J; Sá, MJ; Capela, CObjectives: Natalizumab (NTZ) is very effective for treatment of relapsing-remitting multiple sclerosis (RRMS), its use is mainly limited by safety issues. Discontinuation of NTZ is associated with recurrence of disease activity (reactivation and rebound). The best strategy for subsequent therapy and the predictive factors for recurrence in such patients are areas of active research. We aimed to evaluate predic...
Component digestibility of lupin (Lupinus angustifolius) and pea (Pisum sativum...
Salgado, P; Martins, JM; Carvalho, F; Abreu, M.; Freire, JPB; Toullec, R; Lallès, JP; Bento, O