50 documents found, page 1 of 5
High Incidence of Early Thalamic Lesions in the Continuous Spike-Wave Related w...
Carvalho, D; Mendonça, C; Carvalho, J; Martins, A; Leal, AObjective: Continuous Spike-Wave during slow Sleep (CSWS) syndrome associates a clinically important neurocognitive regression with strong activation of non-REM sleep spikes. Its mechanisms remain unknown, but a contribution of rare perinatal thalamic injuries has been highlighted. We determine the incidence of such lesions in a cohort of CSWS patients. Methods: N = 65 patients with CSWS and a control group (N ...
Spatial and Temporal Dynamics of Epileptic Activity at Sleep Onset in the Encep...
Leal, AEncephalopathy with Status Epilepticus during slow Sleep (ESES) is a syndrome where neurocognitive impairment correlates with multifocal Electroencephalography (EEG) spikes increasing abruptly at sleep onset. Demonstration of a focal onset could provide important clues to unravel the mechanisms underlying the condition, but until know it has not been established.
Interictal spike quantification in continuous spike-wave of sleep (CSWS): Clini...
Carvalho, D; Mendes, T; Dias, AI; Leal, AContinuous spike-wave of sleep (CSWS) syndrome is one of the most common epileptic encephalopathies of childhood. Because the associated cognitive/behavioral disturbances relate more to the amount of spike activity than of seizures, methods of spike quantification gained relevance in diagnosis and monitoring treatment. The conventional methodology for quantification of spike index (SI) relies on repeated full 1...
Regional White Matter Atrophy Correlates with Spike Activity in Encephalopathy ...
Oliveira, AR; Nunes, RG; Figueiredo, P; Dias, AI; Leal, AEncephalopathy related to Status Epilepticus during slow Sleep (ESES) is an age-related, epileptic syndrome, which associates cognitive/behavioral disturbances with a peculiar pattern of spike activity. One promising line of research is the study of ESES in cases of early thalamic lesions. We studied 7 ESES patients with unilateral thalamic lesions using magnetic resonance imaging to assess regional white matte...
Interictal Spike Quantification in Continuous Spike-Wave of Sleep (CSWS): Clini...
Carvalho, D; Mendes, T; Dias, AI; Leal, AContinuous spike-wave of sleep (CSWS) syndrome is one of the most common epileptic encephalopathies of childhood. Because the associated cognitive/behavioral disturbances relate more to the amount of spike activity than of seizures, methods of spike quantification gained relevance in diagnosis and monitoring treatment. The conventional methodology for quantification of spike index (SI) relies on repeated full 1...
Three-Dimensional Speckle-Tracking Echocardiography for the Global and Regional...
Coutinho Cruz, M; Branco, LM; Portugal, G; Galrinho, A; Timóteo, AT; Rio, P; Ilhão Moreira, R; Mendonça, T; Leal, A; Gameiro, F; Duarte Oliveira, SBackground: Assessment of 2D/3D left ventricular ejection fraction (LVEF) and 2D global longitudinal strain (GLS) is the gold standard for diagnosing cancer therapeutics-related cardiac dysfunction (CTRCD). Although 3D speckle-tracking echocardiography (STE) has several advantages, it is not used in this setting. Methods: 105 breast cancer patients who underwent serial echocardiographic assessment during anthra...
Anatomical and Physiological Basis of Continuous Spike-Wave of Sleep Syndrome a...
Leal, A; Calado, E; Vieira, JP; Mendonça, C; Ferreira, JC; Ferreira, H; Carvalho, D; Furtado, F; Gomes, R; Monteiro, JPOBJECTIVE: Early neonatal thalamic lesions account for about 14% of continuous spike-wave of sleep (CSWS) syndrome, representing the most common etiology in this epileptic encephalopathy in children, and promise useful insights into the pathophysiology of the disease. METHODS: We describe nine patients with unilateral neonatal thalamic lesions which progressed to CSWS. Longitudinal whole-night and high-density ...
Dynamics of Epileptic Activity in a Peculiar Case of Childhood Absence Epilepsy...
Leal, A; Vieira, JP; Lopes, R; Nunes, R; Gonçalves, S; Lopes da Silva, F; Figueiredo, PChildhood absence epilepsy (CAE) is a syndrome with well-defined electroclinical features but unknown pathological basis. An increased thalamic tonic GABA inhibition has recently been discovered on animal models (Cope et al., 2009), but its relevance for human CAE is unproven. METHODS: We studied an 11-year-old boy, presenting the typical clinical features of CAE, but spike-wave discharges (SWD) restricted to o...
Motivation and Benefits of Implementation and Certification according ISO 9001 ...
Santos, Gilberto; Costa, José Batista; Leal, AThe aim of the research is to analyze the different aspects associated with the motivation and benefits of certified ISO 9001 companies in Portugal. A total of 426 certified Portuguese companies were surveyed. The response rate was equal to 61.03 percent. Our results suggest that the main motivation for certification were “improvement of quality”, “improvement of company image”, “marketing advantage”, “give emp...
Effects of 8-Month Aquatic Training on Bone Mass Density In Post Menopausal Wom...
Adsuar, JC; Tomas-Carus, P; Parraca, JA; Leal, A; Olivares, PR; Gusi, NObjective: To evaluate the effect of an aquatic training program on bone mass density (BMD) in post- menopausal women with fibromyalgia (FM). Design: Randomised controlled trial (ISRCTN53367487). Settings: Faculty of Sport Science Subjects: Twenty-four postmenopausal women with FM (mean age, 56, SD, 7 years) were randomised to intervention (n=12) or control group (n=12). Interventions: The experimental group re...