4 documents found, page 1 of 1
Broadening Risk Factor or Disease Definition as a Driver for Overdiagnosis: A N...
Bandovas, JP; Leal, B; Reis‐de‐Carvalho, C; Sousa, DC; Araújo, JC; Peixoto, P; Henriques, SO; Vaz Carneiro, AMedical overuse-defined as the provision of health services for which potential harms exceed potential benefits-constitutes a paradigm of low-value care and is seen as a threat to the quality of care. Value in healthcare implies a precise definition of disease. However, defining a disease may not be straightforward since clinical data do not show discrete boundaries, calling for some clinical judgment. And, if ...
Dectin-1-Mediated Production of Pro-Inflammatory Cytokines Induced by Yeast β-G...
Pedro, ARV; Lima, T; Fróis-Martins, R; Leal, B; Ramos, IC; Martins, EG; Cabrita, ARJ; Fonseca, AJM; Maia, MRG; Vilanova, M; Correia, AYeast-derived products containing β-glucans have long been used as feed supplements in domesticated animals in an attempt to increase immunity. β-glucans are mainly recognized by the cell surface receptor CLEC7A, also designated Dectin-1. Although the immune mechanisms elicited through Dectin-1 activation have been studied in detail in mice and humans, they are poorly understood in other species. Here, we evalu...
Two Separate Effects Contribute to Regulatory T Cell Defect in Systemic Lupus E...
Costa, N; Marques, O; Godinho, SI; Carvalho, C; Leal, B; Figueiredo, AM; Vasconcelos, C; Marinho, A; Moraes-Fontes, MF; Gomes da Costa, A; Ponte, CForkhead box P3 (FoxP3)+ regulatory T cells (Tregs ) are functionally deficient in systemic lupus erythematosus (SLE), characterized by reduced surface CD25 [the interleukin (IL)-2 receptor alpha chain]. Low-dose IL-2 therapy is a promising current approach to correct this defect. To elucidate the origins of the SLE Treg phenotype, we studied its role through developmentally defined regulatory T cell (Treg ) su...
A3.6 Two components contributing to reduced treg surface CD25 in sle patients a...
Costa, N; Marques, O; Godinho, S; Carvalho, C; Leal, B; Vasconcelos, C; Marinho, A; Moraes-Fontes, M F; Gomes da Costa, A; Ponte, C; Marques, RBackground FOXP3+ regulatory T-cells (Tregs) in Systemic Lupus Erythematosus (SLE) are in a functionally deficient state with a characteristic reduction or absence of surface CD25 (the IL-2 receptor alpha chain). Genetic variation in the CD25-encoding IL2RA locus is associated with other autoimmune disorders.