6 documents found, page 1 of 1
Transcriptional and molecular pathways activated in mesenteric adipose tissue a...
Coope, Andressa; Biazzo, Lívia Aparecida Davila Bitencourt Pascoal; Silva, Francesca Aparecida Ramos da, 1982-; Botezelli, José DiegoAbstract: Crohn’s disease (CD) is a chronic inflammatory disorder, characterized by cytokine imbalance and transcription signaling pathways activation. In addition, the increase of mesenteric adipose tissue (MAT) near the affected intestinal area is a hallmark of CD. Therefore, we evaluated the transcription signaling pathways and cytokines expression in intestinal mucosa and MAT of active CD patients. Ten pati...
Long-term outcome of perineal rectosigmoidectomy for rectal prolapse
Pinheiro, Lílian Vital, 1986-; Leal, Raquel Franco, 1977-; Coy, Claudio Saddy Rodrigues, 1961-; Fagundes, João Jose, 1943-Abstract: Rectal prolapse is a disabling condition that often affects older patients with multiple comorbidities making complex surgeries impossible to perform. A retrospective review of patients who underwent perineal rectosigmoidectomy (Altemeier procedure) for rectal prolapse from January 1999 to March 2015 was performed in a Reference Hospital, being evaluated complications and surgery recurrence. Thirty-si...
Neoadjuvant therapy and surgery for rectal cancer : comparative study between p...
Andrade, Vitor Augusto de; Coy, Claudio Saddy Rodrigues, 1961-; Leal, Raquel Franco, 1977-; Fagundes, João Jose, 1943-Abstract: The approach of locally advanced extra-peritoneal rectal adenocarcinoma implies a treatment with neoadjuvant chemoradiotherapy associated with total mesorectal excision surgery. However, the tumors respond variably to this neoadjuvant therapy, and the mechanisms for response are not completely understood. Evaluate the variables related to the complete tumor response and the outcomes of patients who un...
Therapies for crohn's disease : a clinical update
Leal, Raquel Franco, 1977-Abstract: The main objectives of clinical therapy in Crohn's disease are clinical and endoscopic remission without the use of corticosteroids for long periods of time, prevention of hospitalization and surgery, and improvement of quality of life. The main limitation of drug therapy is the loss of response over the long term, which makes incorporation of new drugs to the therapeutic arsenal necessary. This revie...
Estudo da atividade inflamatoria e apoptose em reservatorios ileais de doentes ...
Leal, Raquel Franco, 1977-Orientadores: Claudio Saddy Rodrigues Coy, Licio Augusto Velloso; Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas; Resumo: A retocolectomia total com anastomose do reservatório ileal ao canal anal é a cirurgia de escolha para doentes com retocolite ulcerativa inespecífica (RCUI) refratária ao tratamento clínico e para polipose adenomatosa familiar (PAF), com pólipos retais. A...
Expressão das citocinas pro-inflamatorias TNF-a,, IL-1ß, IL-6, IL-8, da protein...
Leal, Raquel Franco, 1977-Orientador: Claudio Saddy Rodrigues Coy; Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas; Resumo: A ileíte do reservatório pós retocolectomia total constitui uma das complicações mais comuns aos doentes com retocolite ulcerativa (RCUI), apresentando pequena freqüência nos doentes com polipose adenomatosa familiar (PAF). Objetivo: Avaliar a atividade inflamatória em muco...