15 documents found, page 1 of 2
Posterior reversible encephalopathy syndrome as a multiple sclerosis relapse mi...
Dias Da Costa, Mariana; Leal Rato, Miguel; Ferreira, João; Sá, João de; Santos, MonicaPosterior reversible encephalopathy syndrome is a rare syndrome involving the subcortical cerebral white matter. We describe the case of a 63-year-old male patient with relapsing remitting multiple sclerosis under interferon beta therapy and acute onset of atypical unilateral posterior reversible encephalopathy syndrome mimicking a relapse. This case highlights the importance of clinical suspicion for multiple ...
Multiple Sclerosis Relapse Incomplete Recovery and Associated Factors - a Syste...
Ladeira, Filipa; Soares, Mafalda; Faustino, Patrícia; Leal Rato, Miguel; Gomes, Inês; Caetano, André; Taipa, Ricardo; Sá, Maria JoséObjectives: We conducted a meta-analysis to assess the frequency of incomplete recovery from multiple sclerosis (MS) relapses and a systematic review to evaluate the influence of six factors on incomplete recovery: relapse severity, age, sex, disease duration, disease-modifying treatment use, and the presence of contrast-enhancing lesions at relapse. Methods: We searched Scientific databases to identify suitabl...
Broadening the Spectrum of Hypnic Headache: A Retrospective Cohort Study
Dourado Sotero, Filipa; Leal Rato, Miguel; Pavão Martins, IsabelIntroduction: Hypnic headache is a rare headache disorder that requires strictly sleep-related attacks. There is also an ill-defined group of patients with recurrent predominant sleep-related nocturnal headache with occasional awake attacks, that are excluded from that diagnosis. Our aim was to compare these different groups and to understand whether their differences justify a distinct diagnosis. Methods: This...
Acute Symptomatic Seizures in Patients with Recurrent Ischemic Stroke: A Multic...
Leal Rato, Miguel; Schön, Miguel; Zafra, Maria Paula; Aguiar de Sousa, Diana; Pinho E Melo, Teresa; Franco, Ana Catarina; Peralta, Ana RitaObjective: Epileptic seizures occur frequently after stroke due to changes in brain function and structure, and up to around 10% of stroke patients experience stroke recurrence in the first year. We aimed to establish the risk of acute symptomatic seizures in patients with recurrent stroke. Methods: Retrospective cohort study including consecutive admissions to a Stroke Unit due to acute ischemic stroke, during...
Online information search by people with Multiple Sclerosis: a systematic review
Berhanu, David; Leal Rato, Miguel; Canhoto, Ana Isabel; Vieira da Cunha, João; Geraldes, RuthBackground: People with Multiple Sclerosis (pwMS) search for information online about various aspects of living with their disease, but details about patterns of searching and outcomes are unclear. This means that opportunities to leverage online resources to support pwMS, and to enhance shared decision making, may be missed. We aimed to do a systematic review of the literature on digital information searching ...
Comorbid autoimmune disorders in people with multiple sclerosis: a retrospectiv...
Leal Rato, Miguel; Santos, Mónica; de Sá, João; Ferreira, JoãoMost autoimmune disorders, including multiple sclerosis (MS), are influenced by shared genetic and environmental factors. We conducted a cohort study of people with MS to calculate the frequency of comorbid autoimmune disorders and characterize this cohort. Autoimmune diseases were present in 30 (8.6%) of 349 patients. The most prevalent diagnoses were autoimmune thyroiditis, type 1 diabetes mellitus, psoriasis...
Online information search by people with multiple sclerosis: a systematic review
Berhanu, David; Leal Rato, Miguel; Canhoto, Ana Isabel; Vieira da Cunha, João; Geraldes, RuthBackground: People with Multiple Sclerosis (pwMS) search for information online about various aspects of living with their disease, but details about patterns of searching and outcomes are unclear. This means that opportunities to leverage online resources to support pwMS, and to enhance shared decision making, may be missed. We aimed to do a systematic review of the literature on digital information searching ...
Neurologic manifestations of the antiphospholipid syndrome : an update
Leal Rato, Miguel; Bandeira, Matilde; Romão, Vasco C.; de Sousa, Diana AguiarPurpose of review: In recent years, the spectrum of neurological manifestations of antiphospholipid syndrome (APS) has been growing. We provide a critical review of the literature with special emphasis on presentation, proposed mechanisms of disease, and treatment of neurological involvement in APS. Recent findings: Although stroke is the most common cause of neurological manifestations in patients with APS, ot...
Neurology of the acute hepatic porphyrias
Oliveira Santos, Miguel; Leal Rato, MiguelPorphyrias are a set of rare inherited metabolic disorders, each of them representing a defect in one of the eight enzymes in the haem biosynthetic pathway resulting in the accumulation of organic compounds called porphyrins. Acute hepatic porphyrias (AHP) are those in which the enzyme deficiency occurs in the liver, of which acute intermittent porphyria is by far the most common subtype. Neurology of the AHP i...
Longitudinally extensive transverse myelitis with anti-myelin oligodendrocyte g...
Dias Da Costa, Mariana; Leal Rato, Miguel; Cruz, Diana; Valadas, Anabela; Antunes, Ana Patrícia; Albuquerque, LuísaWe report the case of a patient with symptoms of myelopathy following acute SARS-CoV-2 infection. MRI documented a longitudinally extensive transverse myelitis and further investigation was unremarkable with the exception of positivity for MOG-IgG in serum. This report extends the spectrum of post-COVID-19 neurological syndromes, and documents a very significant improvement to long-term oral corticosteroid ther...