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The Na+ -Coupled Glucose Transporter SGLT2 Interacts with its Accessory Unit MA...

Calado, J; Santos, AR; Aires, I; Lebre, F; Nolasco, F; Rueff, J; Ramalho, J

Na+ -glucose cotransporter 2 is the renal Na+ -coupled glucose transporter responsible for the tubular glucose reabsorption, while MAP17 was recently identified as its accessory unit. Mutations in either of the proteins' coding genes, SLC5A2 and PDZK1IP1, lead to urinary glucose excretion. To investigate whether MAP17 interacts with SGLT2 in vitro, we engineered a V5-tagged SGLT2 construct and evaluated HEK293T...

Date: 2018   |   Origin: Repositório do Centro Hospitalar de Lisboa Central, EPE
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