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Bmpr2 Mutant Rats Develop Pulmonary and Cardiac Characteristics of Pulmonary Ar...
Hautefort, A; Mendes Ferreira, P; Sabourin, J; Manaud, G; Bertero, T; Rucker Martin, C; Riou, M; Adao, R; Manoury, B; Lambert, M; Boet, A; Lecerf, FBACKGROUND: Monoallelic mutations in the gene encoding bone morphogenetic protein receptor 2 (Bmpr2) are the main genetic risk factor for heritable pulmonary arterial hypertension (PAH) with incomplete penetrance. Several Bmpr2 transgenic mice have been reported to develop mild spontaneous PAH. In this study, we examined whether rats with the Bmpr2 mutation were susceptible to developing more severe PAH. METHOD...
Date: 2019
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Origin: Repositório Aberto da Universidade do Porto