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Insights on mycobacterium leprae efflux pumps and their implications in drug re...

Machado, Diana; Lecorche, Emmanuel; Mougari, Faiza; Cambau, Emmanuelle; Viveiros, Miguel

Drug resistance in Mycobacterium leprae is assumed to be due to genetic alterations in the drug targets and reduced cell wall permeability. However, as observed in Mycobacterium tuberculosis, drug resistance may also result from the overactivity of efflux systems, which is mostly unexplored. In this perspective, we discuss known efflux pumps involved in M. tuberculosis drug resistance and virulence and investig...

Date: 2018   |   Origin: Repositório Institucional da UNL
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