4 documents found, page 1 of 1
A hybrid bi-objective optimization approach for joint determination of safety s...
Silva, Pedro M.; Gonçalves, João N. C.; Martins, Tiago M.; Marques, Luís C.; Oliveira, Miguel; Reis, Marcelo I.; Araújo, Luís; Correia, DanielaIn material requirements planning (MRP) systems, safety stock and safety time are two well-known inventory buffering strategies to protect against supply and demand uncertainties. While the role of safety stocks in coping with uncertainty is well studied, safety time has received only scarce attention in the supply chain management literature. Particularly, most previous operations research models have typicall...
Besnoitia besnoiti protein disulfide isomerase (BbPDI): molecular characterizat...
Marcelino, Eduardo; Martins, Tiago M.; Morais, Joana B.; Nolasco, Sofia; Cortes, Helder; Hemphill, Andrew; Leitão, Alexandre; Novo, CarlosBesnoitia besnoiti is an apicomplexan parasite responsible for bovine besnoitiosis, a disease with a high prevalence in tropical and subtropical regions and re-emerging in Europe. Despite the great economical losses associated with besnoitiosis, this disease has been underestimated and poorly studied, and neither an effective therapy nor an efficacious vaccine is available. Protein disulfide isomerase (PDI) is ...
Plasmodium chabaudi
Caldeira, Rubina L.; Goncalves, Lidia M. D.; Martins, Tiago M.; Silveira, Henrique; Novo, Carlos; do Rosario, Virgilio; Domingos, AnaPlasmodium cysteine proteases have been shown to be immunogenic and are being used as malaria potential serodiagnostic markers and vaccine targets. Genes encoding two Plasmodium chabaudi cysteine proteases chabaupain-1 (CP-1) and chabaupain-2 (CP-2) were identified and further expressed in Escherichia coli. Solubilisation of recombinant CP-1 and CP-2 was achieved by decreasing the temperature of induction. Anop...
Detection of bovine Babesiosis in Mozambique by a novel seminested hot-start PC...
Martins, Tiago M.; Pedro, Olívia C.; Rubina, Caldeira; Rosário, Virgílio do; Neves, L.; Domingos, AnaBabesiosis is a tick borne disease (TBD) caused by parasites of the genus Babesia, with considerable worldwide economic, medical, and veterinary impact. Bovine babesiosis and other TBDs were considered responsible for 50% of the deaths of cattle that occurred in Mozambique in the first year after importation from neighbouring countries. Here, we present the detection of Babesia bigemina and Babesia bovis in cat...