3 documents found, page 1 of 1
S327 phosphorylation of the presynaptic protein SEPTIN5 increases in the early ...
Ferreira, Catarina B.; Marttinen, Mikael; Coelho, Joana E; Paldanius, Kaisa M.A.; Takalo, Mari; Mäkinen, Petra; Leppänen, LuukasAlzheimer's disease (AD) is the most common form of dementia, which is neuropathologically characterized by extracellular senile plaques containing amyloid-β and intracellular neurofibrillary tangles composed of hyperphosphorylated tau protein. Previous studies have suggested a role for septin (SEPTIN) protein family members in AD-associated cellular processes. Here, we elucidated the potential role of presynap...
Presynaptic vesicle protein SEPTIN5 regulates the degradation of APP C-Terminal...
Marttinen, Mikael; Ferreira, Catarina B.; Paldanius, Kaisa M. A.; Takalo, Mari; Natunen, Teemu; Mäkinen, Petra; Leppänen, Luukas; Leinonen, VilleAlzheimer's disease (AD) is a neurodegenerative disease characterized by aberrant amyloid-β (Aβ) and hyperphosphorylated tau aggregation. We have previously investigated the involvement of SEPTIN family members in AD-related cellular processes and discovered a role for SEPTIN8 in the sorting and accumulation of β-secretase. Here, we elucidated the potential role of SEPTIN5, an interaction partner of SEPTIN8, in...
Chasing the Effects of Pre-Analytical Confounders - A Multicenter Study on CSF-...
Leitão, Maria João; Baldeiras, Inês; Herukka, Sanna-Kaisa; Pikkarainen, Maria; Leinonen, Ville; Simonsen, Anja Hviid; Perret-Liaudet, ArmandIntroduction: Core cerebrospinal fluid (CSF) biomarkers – Aβ42, Tau, and phosphorylated Tau (pTau) – have been recently incorporated in the revised criteria for Alzheimer’s disease (AD). However, their widespread clinical application lacks standardization. Preanalytical sample handling and storage play an important role in the reliable measurement of these biomarkers across laboratories. Aim: In this study, we ...