51 documents found, page 1 of 6

Molecular Profile of Sensitization to Dermatophagoides Pteronyssinus Dust Mite ...

Background and objectives: To analyze component-resolved diagnosis of sensitization to Dermatophagoides pteronyssinus (Der p) in patients with respiratory allergy and the association between diagnostic findings and clinical severity in different geographical areas. Methods: The study population comprised 217 patients (mean age, 25.85 [12.7] years; 51.16% female) selected from 13 centers in Portugal (5 from the ...

Secondary Adrenal Suppression Related to High Doses of Inhaled Corticosteroids ...

Immunoallergic Disorders in the Elderly

Although allergic diseases have become increasingly prevalent in the elderly, there are few data on this population. Through a retrospective analysis of the electronic medical records of patients aged 65 years and above followed in our Immunoallergology Unit, we aimed to characterize the immunoallergic diseases of the elderly. The most common disorders were respiratory diseases (n = 185; 50%), mucocutaneous dis...

Cisatracúrio – Um Relaxante Neuromuscular “Seguro”?

Os agentes anestésicos representam uma causa importante de anafilaxia a fármacos, sendo os relaxantes neuromusculares (RNM) dos principais responsáveis pelos casos de anafilaxia perioperatória. O cisatracúrio é o RNM mais recente, sendo um estereoisómero do atracúrio que se acreditava não ter potencial de libertação de histamina e, consequentemente, causar menos reações alérgicas do que os outros RNM. No entant...

Cross-Cultural Validation of the Portuguese from Portugal Version of the Test f...

Introduction. The Test for Respiratory and Asthma Control in Kids (TRACK) is a tool to assess asthma control in preschool children. This study aims to validate the Portuguese from Portugal version of the TRACK questionnaire. Methods. A prospective cohort study was carried out to assess their psychometric characteristics. Caregivers of 141 children under age 5 with asthma symptoms were enrolled. Results. Interna...

Factors Associated With Asthma Control in 121 Preschool Children

Background and objectives: Data on risk factors for uncontrolled asthma in preschool children are controversial. Objective: This study aims to explore the association between clinical and functional parameters and the lack of asthma control in preschool children. Methods: Children aged 3-5 years with asthma and healthy controls were recruited. A questionnaire was used to identify potential risk factors for unco...

Factors Associated With Asthma Control in 121 Preschool Children

Background: Data on risk factors for uncontrolled asthma in preschool children are controversial. Objective: This study aims to explore the association between clinical and functional parameters and the lack of asthma control in preschool children. Methods: Children aged 3-5 years with asthma and healthy controls were recruited. A questionnaire was used to identify potential risk factors for uncontrolled asthma...

Profiling Persistent Asthma Phenotypes in Adolescents: A Longitudinal Diagnosti...

We aimed to identify persistent asthma phenotypes among adolescents and to evaluate longitudinally asthma-related outcomes across phenotypes. Adolescents (13-17 years) from the prospective, observational, and multicenter INSPIRERS studies, conducted in Portugal and Spain, were included (n = 162). Latent class analysis was applied to demographic, environmental, and clinical variables, collected at a baseline med...

Eosinófilos e IL-5 – Novos Horizontes no Tratamento da Asma e outras Doenças Eo...

Os eosinófilos participam na defesa do hospedeiro como células do sistema imune inato, mas estão também associados a diversas patologias. Recentemente, tem-se questionado se a acumulação destas células em patologias associadas a eosinofilia tem apenas efeitos patológicos ou se desempenha também um papel nos mecanismos de resposta homeostáticos. A interleucina-5 (IL-5) é a principal citocina envolvida na produçã...

Tratamento Sistémico do Eczema Atópico Grave em Idade Pediátrica

O eczema atópico (EA) é uma doença inflamatória crónica muito frequente em idade pediátrica. Na maioria dos casos o controlo clínico é alcançado com o recurso a hidratação adequada (emolientes) e a medicação tópica (corticosteroides tópicos, inibidores da calcineurina tópicos) embora exista um subgrupo de doentes com EA grave que não responde ao tratamento convencional ou que tem recidivas após a redução do mes...