11 documents found, page 1 of 2

Cutaneous IgG4-Related Disease Treated with Dupilumab

We present a 59-year-old male with a prolonged history of severe, treatment-resistant pruritic dermatosis and associated systemic symptoms, including fatigue and diarrhea. Dermatologic examination revealed widespread erythematous-brownish papules and nodules, prompting a skin biopsy that showed dense infiltration by immunoglobulin G4 (IgG4)-positive plasma cells, leading to a diagnosis of IgG4-related disease (...

Episódio hipotónico-hiporresponsivo pós-vacinação: a propósito de um caso clínico

Introdução: O episódio hipotónico-hiporresponsivo (EHH) pós-vacinação caracteriza-se pela súbita diminuição do tónus muscular, hiporresponsividade e alteração da coloração cutânea (palidez ou cianose), com início imediato ou até 48 horas pós-imunização e em que não é identificável outra causa.Descrição do caso: Descreve-se o caso clínico de uma lactente referenciada à consulta por suspeita de anafilaxia após va...

The Portuguese Severe Asthma Registry: Development, Features, and Data Sharing ...

The Portuguese Severe Asthma Registry (Registo de Asma Grave Portugal, RAG) was developed by an open collaborative network of asthma specialists. RAG collects data from adults and pediatric severe asthma patients that despite treatment optimization and adequate management of comorbidities require step 4/5 treatment according to GINA recommendations. In this paper, we describe the development and implementation ...

Chronic respiratory diseases and quality of life in elderly nursing home residents

Few studies have assessed the quality of life (QOL) related to chronic respiratory diseases in the elderly. In the framework of the geriatric study on the health effects of air quality in elderly care centers (GERIA) study, a questionnaire was completed by elderly subjects from 53 selected nursing homes. It included various sections in order to assess respiratory complaints, QOL (World Health Organization QOL (...

Effect of indoor air quality of day care centers in children with different pre...

BACKGROUND: Scarce information is available about the relationships between indoor air quality (IAQ) at day care centers (DCC), the estimated predisposition for asthma and the actual wheezing susceptibility. METHODS: In the Phase II of ENVIRH study, 19 DCC were recruited after cluster analysis. Children were evaluated firstly using the ISAAC questionnaire and later by a follow up questionnaire about recent whee...

Reported Drug Allergy among Children Attending Day Care Centers

Introduction: Data about drug allergy prevalence in the general population, particularly in children, are lacking. This study aimed to estimate the prevalence of parent-reported drug allergy, in children attending day care centers in Lisbon and Oporto.Material and Methods: In Phase II of the “ENVIRH study – Environment and Health in Children Day Care Centers”, a health questionnaire which included questions abo...

CO2 concentration in day care centres is related to weezing in attending children

Poor ventilation at day care centres (DCCs) was already reported, although its effects on attending children are not clear. This study aimed to evaluate the association between wheezing in children and indoor CO2 (a ventilation surrogate marker) in DCC and to identify behaviours and building characteristics potentially related to CO2. In phase I, 45 DCCs from Lisbon and Oporto (Portugal) were selected through a...

DRUG ALLERGY WITH CUTANEOUS MANIFESTATIONS - DIAGNOSTIC APPROACH

Adverse drug reactions constitute a major health problem in clinical practice. Drug allergy is defined as an immunologically mediated hypersensitivity reaction and represents 6-10% of all adverse drug reactions. Cli- nically, drug-induced allergic reactions can be classified as immediate (type I) and non-immediate (heterogeneous clinical manifestations, mostly related to type IV reactions). Several issues are c...

Volatile organic compounds in day care centers constitute a risk factor for abs...

Indoor Air Quality in Portuguese Day Care Centers - ENVIRH Project

This paper describes field measurements of indoor air quality (IAQ) parameters, performed in 19 Portuguese Children Day Care Centers (CDCC) during the springtime of 2011 and aims to characterize the indoor environment. The results demonstrate an association between carbon dioxide and bacterial concentrations, which in turn are affected by the number of children present in each classroom. Indoor PM10 concentrati...