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Cross-Kingdom Enzymatic Strategies for Deoxynivalenol Detoxification

Enguita, Francisco J.; Leitão, Ana Lúcia

Deoxynivalenol (DON) is a trichothecene mycotoxin produced by Fusarium species that frequently contaminates cereal crops, representing a major threat to food safety, public health, and agricultural productivity. Its remarkable chemical stability during food processing presents significant challenges for effective detoxification. Among the available mitigation strategies, biological approaches have emerged as pa...


The Unpaved Road of Non-Coding RNA Structure–Function Relationships

Leitão, Ana Lúcia; Enguita, Francisco J.

The genomes from complex eukaryotes are enriched in non-coding genes whose transcription products (non-coding RNAs) are involved in the regulation of genomic output at different levels. Non-coding RNA action is predominantly driven by sequence and structural motifs that interact with specific functional partners. Despite the exponential growth in primary RNA sequence data facilitated by next-generation sequenci...


Portuguese Youth Saving Determinants of Financial Literacy

Leitão, Ana Lúcia; Silva, Mónica; Abreu, Margarida; Fitas, Filipa; Ricardo ,Tiago

his study aims to characterise the saving behaviour of Portuguese people, by analysing factors that influence financial decisions, such as the socio-economic and behavioural variables that determine saving and the impact of financial literacy on their willingness to save. We conclude that individuals with 31 or more years of age, with high levels of education, higher income, average financial knowledge and who ...


RNA Regulatory Networks 2.0

Enguita, Francisco J.; Leitão, Ana Lúcia; Mattick, John S.

The central role of RNA molecules in cell biology has been an expanding subject of study since the proposal of the "RNA world" hypothesis 60 years ago [...].


Literacia em saúde e alimentação em estudantes do ensino superior

Ferreira, Manuela; Leitão, Ana Lúcia; Campos, Sofia; Ferreira Aparício Costa, Maria Da Graça; Guiné, Raquel P. F.


Comparação de três métodos para deteção de Salmonella em diversos géneros alime...

Furtado, Rosália; Coelho, Anabela; Morais, Marisa; Leitão, Ana Lúcia; Saraiva, Margarida; Correia, Cristina Belo; Batista, Rita

Em 2020, de acordo com os dados, reportados por 22 Estados-membros e 5 Estados não-membros, constantes do The European Union One Health 2020 Zoonoses Report, elaborado em conjunto pela European Food Safety Authority (EFSA) e pelo European Centre for Disease Prevention and Control (ECDC), Salmonella foi o principal agente etiológico responsável por surtos de origem alimentar, estando envolvida em 694 surtos, que...


Promoção de saúde da mulher : desafios e tendências

Coutinho, Emília; Dias, Hélia; Santos, Maria José; Leitão, Ana Lúcia; Pires, Ana Sofia; Feliciano, Anabela; Pereira, Carolina Novado

A enfermagem de saúde materna e obstétrica focada na saúde sexual e reprodutiva apresenta-se como eixo central nesta edição didática, de cariz metodológico. São apresentados oito artigos de revisão, seis utilizam o método de revisão integrativa da literatura e dois artigos utilizam a Scoping Review, com vista à identificação ou mapeamento da síntese do conhecimento produzido. As temáticas apresentadas são as se...


Deteção de Salmonella em géneros alimentícios - Comparação de métodos

Furtado, Rosália; Coelho, Anabela; Leitão, Ana Lúcia; Saraiva, Margarida; Belo Correia, Cristina; Batista, Rita

Na União Europeia (UE), a Salmonella foi o agente etiológico responsável por cerca de um em cada três (30,7%) de todos os surtos de origem alimentar notificados pelos estados-membros, durante o ano de 2018, causando 11 581 casos de doença, o que representa um aumento de 20,6% em relação a 2017. Considerando a importância desta bactéria zoonótica de origem alimentar na segurança alimentar e na saúde humana, vári...


Structural insights into carboxylic polyester-degrading enzymes and their funct...

Leitão, Ana Lúcia; Enguita, Francisco J.

Esters are organic compounds widely represented in cellular structures and metabolism, originated by the condensation of organic acids and alcohols. Esterification reactions are also used by chemical industries for the production of synthetic plastic polymers. Polyester plastics are an increasing source of environmental pollution due to their intrinsic stability and limited recycling efforts. Bioremediation of ...


Systematic structure-based search for Ochratoxin-degrading enzymes in Proteomes...

Leitão, Ana Lúcia; Enguita, Francisco J.

Background: ochratoxins are mycotoxins produced by filamentous fungi with important implications in the food manufacturing industry due to their toxicity. Decontamination by specific ochratoxin-degrading enzymes has become an interesting alternative for the treatment of contaminated food commodities. Methods: using a structure-based approach based on homology modeling, blind molecular docking of substrates and ...


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