6 documents found, page 1 of 1
Cd44v6 high membranous expression is a predictive marker of therapy response in...
Almeida, GM; Pereira, C; Park, JH; Lemos, C; Campelos, S; Gullo, I; Martins, D; Gonçalves, G; Leitão, D; Neto, JL; André, A; Borges, C; Almeida, DIn gastric cancer (GC), biomarkers that define prognosis and predict treatment response remain scarce. We hypothesized that the extent of CD44v6 membranous tumor expression could predict prognosis and therapy response in GC patients. Two GC surgical cohorts, from Portugal and South Korea (n = 964), were characterized for the extension of CD44v6 membranous immuno-expression, clinicopathological features, patient...
Risk Factors for Breast Cancer, Overall and by Tumor Subtype, among Women from ...
Brandão, M; Guisseve, A; Damasceno, A; Bata, G; Silva-Matos, C; Alberto, M; Ferro, J; Garcia, C; Zaqueu, C; Lorenzoni, C; Leitão, D; Soares, OBackground: Breast cancer incidence is rising in Africa, but there are scare data regarding risk factors in this region. We assessed the relation between risk factors and the occurrence of breast cancer, overall and by tumor subtype in women from Mozambique. Methods: The associations between education, number of births, height, weight, body mass index (BMI), and breast cancer risk among 138 cases (participants ...
Survival Impact and Cost-Effectiveness of a Multidisciplinary Tumor Board for B...
Brandão, M; Guisseve, A; Bata, G; Firmino-Machado, J; Alberto, M; Ferro, J; Garcia, C; Zaqueu, C; Jamisse, A; Lorenzoni, C; Piccart-Gebhart, MBackground Despite the international endorsement of multidisciplinary tumor boards (MTBs) for breast cancer care, implementation is suboptimal worldwide, and evidence regarding their effectiveness in developing countries is lacking. We assessed the impact on survival and the cost-effectiveness of implementing an MTB in Mozambique, sub-Saharan Africa. Materials and Methods This prospective cohort study included ...
The role of c-Met and VEGFR2 in glioblastoma resistance to bevacizumab
Carvalho, B; Lopes, JM; Silva, R; Peixoto, J; Leitão, D; Soares, P; Fernandes, AC; Linhares, P; Vaz, R; Lima, JDismal prognosis of glioblastoma (GBM) prompts for the identification of response predictors and therapeutic resistance mechanisms of current therapies. The authors investigated the impact of c-Met, HGF, VEGFR2 expression and microvessel density (MVD) in GBM patients submitted to second-line chemotherapy with bevacizumab. Immunohistochemical expression of c-Met, HGF, VEGFR2, and MVD was assessed in tumor specim...
The adaptive immune landscape of the colorectal adenoma–carcinoma sequence
Freitas, JA; Gullo, I; Garcia, D; Miranda, S; Spaans, L; Pinho, L; Reis, J; Sousa, F; Baptista, M; Resende, C; Leitão, D; Durães, C; Costa, JLBackground. The tumor immune microenvironment exerts a pivotal influence in tumor initiation and progression. The aim of this study was to analyze the immune context of sporadic and familial adenomatous polyposis (FAP) lesions along the colorectal adenoma–carcinoma sequence (ACS). Methods. We analyzed immune cell counts (CD3+, CD4+, CD8+, Foxp3+, and CD57+), tumor mutation burden (TMB), MHC-I expression and PD-...
Breast cancer subtypes: implications for the treatment and survival of patients...
Brandão, M; Guisseve, A; Bata, G; Alberto, M; Ferro, J; Garcia, C; Zaqueu, C; Lorenzoni, C; Leitão, D; Come, J; Soares, O; Gudo-Morais, A; Schmitt, FBackground. Data regarding breast cancer epidemiology, treatment and survival in Africa are scarce. We aimed to assess the distribution of breast cancer subtypes in Mozambique and its impact on patients’ treatment and survival. The concordance of biomarker assessment between cytological and histological samples was also evaluated. Methods. Prospective cohort study including 210 patients diagnosed between Januar...