9 documents found, page 1 of 1

Development of a Metric of Aquatic Invertebrates for Volunteers (MAIV): A Simpl...

Citizen science activities, involving local people in volunteer-supported and sustainable monitoring programs, are common. In this context, the objective of the present work was to develop a simple Metric of Aquatic Invertebrates for Volunteers (MAIV), including a user-friendly tool that can be easily accessed by volunteers, and to evaluate the efficiency of a volunteer monitoring program following an audit pro...

Assessing the impact of environmental forcing on the condition of anchovy larva...

Understanding the environmental processes affecting fish larvae survival is critical for population dynamics, conservation purposes and to ecosystem-based fishery management. Using anchovies (Engraulis encrasicolus) of the Cadiz Gulf as a study case and considering the “Ocean Triad” hypothesis, we investigate the larval ecophysiological status and potential survival in relation to oceanographic variables. There...

Extended characterization of lipidic profile: evaluation of lipoprotein subfrac...

Dyslipidaemia is one major cause for atherosclerosis and cardiovascular disease. Atherogenicity of LDL particles vary with particle size, density and lipid composition. Smaller and denser subparticles are more atherogenic than the larger ones, so it’s important to quantify and know the type of sdLDL present in an individual in order to access cardiovascular risk. The aim of this study is to compare and evaluate...

Cascade Screening in Familial Hypercholesterolemia importance in early detection

Familial hypercholesterolemia (FH) is a genetic condition mainly caused by mutations in LDLR but missense mutations in APOB and PCSK9 can cause similar phenotypes. FH is characterized by increased levels of LDL cholesterol, leading to premature cardiovascular diseases (CVD). Cascade screening (CS) allows the rapid identification of new FH cases within a family. The main goal of this work is to perform CS of FH ...

Portuguese experience on cascade screening of index patients with FH

Familial hypercholesterolaemia (FH) is an inherited disorder of cholesterol metabolism caused by mutations in LDLR, APOB and PCSK9 genes. FH has a estimated frequency of 1:500 in most European countries. Based on this frequency Portugal should have about 20000 cases of FH, however in our country this disorder is under-diagnosed.

The impact of cascade screening in familial hypercholesterolemia diagnosis

Familial hypercholesterolemia (FH) is a genetic disorder of cholesterol metabolism caused by mutations in LDLR, APOB and PCSK9 genes. It’s characterized by an increase of total and LDL cholesterol levels leading to premature cardiovascular disease. According to the frequency of the disease in most European countries (1:500 individuals) it is estimated that in Portugal exists about 20.000 cases of FH, but this d...

Portuguese experience on cascade screening of index patients with FH

O método de cascade screening na identificação de doentes com hipercolesterolem...

A Hipercolesterolemia Familiar (FH) é uma doença genética do metabolismo lipídico causada por mutações nos genes LDLR, APOB e PCSK9. Caracteriza-se clinicamente por níveis elevados de colesterol LDL, que se vão depositando nas artérias conduzindo ao desenvolvimento de doenças cardiovasculares prematuras. De acordo com a frequência europeia (1:500) estima-se que existam cerca de 20.000 indivíduos afectados com F...

CA-125 AUC as a new prognostic factor for patients with ovarian cancer

Prémio atribuído pelo International Research Promotion Council a Amílcar C. Falcão: Eminent Scientist of the Year 2006. Europe; Abstract Objective The aim of the present study was to investigate the usefulness of the CA-125 area under the curve (AUC) as a new kinetic parameter for predicting overall survival in patients with ovarian cancer. In addition, the relationship of CA-125 AUC with other prognostic facto...