20 documents found, page 1 of 2
Whole-genome sequencing of Landim pigs of Mozambique reveals a close relationsh...
Teixeira, F; Sá, P; Santos, D; Garrine, C; Zimba, L; Souza, L; Chiaia, H; Leitão, L; Cordeiro, JM; Gama, LT; Amaral, AJLandim pigs, a population of native pigs from Mozambique are currently threatened by the recent introduction of European exotic breeds. Like most African pig populations, Landim pigs have never been characterized at the genome level and are well adapted to harsh conditions which include adaptation to endemic diseases. In this study, we provide a comprehensive genetic characterization of Landim pigs using whole-...
Hypophosphatemia As a Possible Biomarker for Epileptic Seizures at the Emergenc...
Coutinho, M; Faustino, P; Ladeira, F; Leitão, LIntroduction: Hypophosphatemia seems to be temporally associated with seizures, despite not being considered a trigger. We aimed to evaluate hypophosphatemia as a biomarker for seizures. Methods: Retrospective study, including all consecutive patients admitted at our central hospital's emergency department from 01/01-31/03/2021, screened as "altered consciousness/syncope" or "seizures", with available phosphate...
Seroconversion Rate Following HBV Vaccination in Clinical Practice: The Role of...
Faustino, P; Coutinho, M; Leitão, L; Capela, C; Brum, M; Parra, J; Sequeira, J; Barros, A; Araújo, C; Sousa, A; Ladeira, FHBV screening and immunization is recommended in all MS patients and is mandatory before the start of some DMT. However, studies evaluating the immune response to HBV vaccine in MS patients are scarce. We aimed to evaluate the seroprotection rate following HBV immunization in MS patients and to assess if older age and DMT-treatment influenced seroprotection. We conducted a cohort study between 2016 and 2020 and...
Osteoblasts are inherently programmed to repel sensory innervation
Leitão, L; Neto, E; Conceição, F; Monteiro, AC; Couto, M; Alves, CJ; Sousa, DM; Lamghari, MTissue innervation is a complex process controlled by the expression profile of signaling molecules secreted by tissue-resident cells that dictate the growth and guidance of axons. Sensory innervation is part of the neuronal network of the bone tissue with a defined spatiotemporal occurrence during bone development. Yet, the current understanding of the mechanisms regulating the map of sensory innervation in th...
Nociceptive mechanisms driving pain in a post-traumatic osteoarthritis mouse model
Alves, CJ; Couto, M; Sousa, DM; Magalhães, A; Neto, E; Leitão, L; Conceição, F; Monteiro, AC; Ribeiro-da-Silva, M; Lamghari, MIn osteoarthritis (OA), pain is the dominant clinical symptom, yet the therapeutic approaches remain inadequate. The knowledge of the nociceptive mechanisms in OA, which will allow to develop effective therapies for OA pain, is of utmost need. In this study, we investigated the nociceptive mechanisms involved in post-traumatic OA pain, using the destabilization of the medial meniscus (DMM) mouse model. Our resu...
A multicenter, non-interventional study to evaluate the disease activity in Mul...
Ladeira, F; Braz, L; Salgado, P; Vaz, S; Leitão, L; Félix, C; Salgado, V, et al.Abstract OBJECTIVES: Natalizumab (NTZ) is very effective for treatment of relapsing-remitting multiple sclerosis (RRMS), its use is mainly limited by safety issues. Discontinuation of NTZ is associated with recurrence of disease activity (reactivation and rebound). The best strategy for subsequent therapy and the predictive factors for recurrence in such patients are areas of active research. We aimed to evalua...
Prescrição de Anti-Inflamatórios Não Esteroides a Doentes com Diabetes Mellitus...
Vieira, M; Neves, JS; Baptista, R; Leitão, L; Dias, C; Vicente, R, et al.INTRODUCTION: Portugal presents the highest incidence of stage 5 chronic kidney disease in Europe. It is speculated that a high consumption of non-steroidal anti-inflammatory drugs (NSAIDS) may contribute to this high incidence. Our aim was to characterize the prescription of non-steroidal anti-inflammatory drugs to patients with diabetes mellitus in Portugal. MATERIAL AND METHODS: We analyzed the national pres...
Lower free triiodothyronine levels within the reference range are associated wi...
Neves, JS; Leitão, L; Baptista, R, et al.BACKGROUND: Thyroid hormones play a central role in cardiovascular homeostasis. Lower free triiodothyronine (FT3) levels have been associated with worse prognosis in several conditions. However, contrary to thyrotropin (TSH) and free thyroxine (FT4), the role of FT3 in morbidity and mortality in the general population remains uncertain. Our objective was to evaluate the association between within the normal ran...
Lower Free Triiodothyronine Levels Within the Reference Range Are Associated wi...
Neves, JS; Leitão, L; Baeta Baptista, R; Bigotte Vieira, M; Magriço, R; Viegas Dias, C; Oliveira, A; Falcão-Pires, I; Lourenço, A; Carvalho, DThyroid hormones play a central role in cardiovascular homeostasis. Lower free triiodothyronine (FT3) levels have been associated with worse prognosis in several conditions. However, contrary to thyrotropin (TSH) and free thyroxine (FT4), the role of FT3 in morbidity and mortality in the general population remains uncertain. Our objective was to evaluate the association between within the normal range FT3 level...
Intensive Blood Pressure Treatment Reduced Stroke Risk in Patients With Albumin...
Leitão, L; Soares-Dos-Reis, R; Neves, JS; Baptista, RB; Bigotte Vieira, M; Mc Causland, FRBackground and Purpose- Albuminuria is associated with stroke risk among individuals with diabetes. However, the association of albuminuria with incident stroke among nondiabetic patients is less clear. Methods- We performed a post hoc analysis of the SPRINT (Systolic Blood Pressure Intervention Trial), which examined the effect of higher versus lower intensity blood pressure management on mortality in 8913 par...