5 documents found, page 1 of 1
Person-centered health intervention programs provided at home to older adults w...
Nascimento, Vânia; Lopes, Mauro G.; Leitão, Miguel M.; Fonseca, César; Alves, Elisabete; Bico, Isabel; Pinho, Lara GuedesThere is a high rate of morbidity and considerable functional dependence in older adults, requiring care from informal caregivers. Person-centered care is a personalized approach that meets the person’s needs, taking their context into account. Objectives: Our aim was to assess the available evidence on Person-Centered Health Intervention Programs (PCHCIPs) in a home setting among older adults with multimorbidi...
Targeting quorum sensing: ferulic and sinapic acids compromise Pseudomonas aeru...
Leitão, Miguel M.; Borges, Fernanda; Simões, Manuel; Borges, AnabelaBackground: Pseudomonas aeruginosa is a Gram-negative pathogenic bacterium that is frequently associated with chronic infections in immunocompromised individuals, such as those with cystic fibrosis or burns [1]. The pathogenicity and virulence of P. aeruginosa are primarily regulated by quorum sensing, with the las system playing a key role in this process. This system is essential for the formation and mainten...
Two cinnamic acid derivatives as inhibitors of Pseudomonas aeruginosa las and p...
Leitão, Miguel M.; Gonçalves, Ariana S.C.; Sousa, Sérgio F; Borges, Fernanda; Simões, Manuel; Borges, AnabelaIntroduction: Quorum sensing (QS) is a bacterial communication mechanism that regulates gene expression, playing a crucial role in various physiological processes. Interfering with this signalling pathway is a promising strategy to control bacterial pathogenicity and virulence. Objectives: This study evaluated the potential of two cinnamic acid derivatives, ferulic and sinapic acids, to inhibit the las and pqs ...
Efficacy of selected phenolic acids in inhibiting the LasI/LasR and PQS quorum ...
Leitão, Miguel M.; Borges, Fernanda; Simões, Manuel; Borges, AnabelaBackground: Quorum sensing (QS) is a bacterial intercellular communication mechanism mediated by extracellular signalling molecules known as autoinducers [1]. LasI/LasR and pseudomonas quinolone signalling (PQS) are fundamental components of the QS system in Pseudomonas aeruginosa. These systems perform a crucial role in the regulation of gene expression in response to cell density, coordination of bi...
Sulfobetaine methacrylate-functionalized graphene oxide-IR780 nanohybrids aimed...
Leitão, Miguel M.; Alves, Cátia G.; de Melo-Diogo, Duarte; Lima-Sousa, Rita; Moreira, André F.; Correia, Ilídio J.The application of Graphene Oxide (GO) in cancer photothermal therapy is hindered by its lack of colloidal stability in biologically relevant media and modest Near Infrared (NIR) absorption. In this regard, the colloidal stability of GO has been improved by functionalizing its surface with poly(ethylene glycol) (PEG), which may not be optimal due to the recent reports on PEG immunogenicity. On the other hand, t...