13 documents found, page 1 of 2
Spherical neutral gold nanoparticles improve anti-inflammatory response, oxidat...
Carvalho, Thaís Gomes de; Garcia, Vinícius Barreto; Araújo, Aurigena Antunes de; Gasparotto, Luiz Henrique da Silva; Silva, HeloizaThis study aimed to elucidate the anti-inflammatory, anti-oxidant and antifibrotic effects of gold nanoparticles (GNPs) in rats subjected to liver injury with ethanol and Methamphetamine (METH). The liver injury was induced by gavage administrations of 30% alcoholic solution (7 g/kg) once a day during 28 days, followed by METH (10 mg/kg) on the 20th and 28th days of treatment. GNPs treatment (724.96 µg/kg) duri...
Analysis of the immunoexpression of opioid receptors and their correlation with...
Sousa, Alceu Machado de; Dantas, Thinali Sousa; Silva, Paulo Goberlânio de Barros; Martins, Conceição da Silva; Freire, Gildenio EstevamObjective: Breast cancer is a disease of great concern. The prognosis of this tumor is related to its staging. Opioids are widely used to minimize pain in oncology clinics; however, the relationship between the administration of opioids and their effects on tumor cells has yet to be elucidated. Therefore, this study aimed to evaluate the immunoexpression of mu- (μ) and kappa- (κ) opioid receptors and their corr...
The effect of high concentration of zoledronic acid on tooth induced movement a...
Sousa, Fátima Regina Nunes de; Ferreira, Vanessa Costa de Sousa; Martins, Conceição da Silva; Dantas, Hugo Victor; Sousa, Frederico Barbosa deZoledronic acid (ZA) is often prescribed for osteoporosis or resorptive metabolic bone disease. This study aims to evaluate the effect of ZA on orthodontic tooth movement (OTM) and root and bone resorption and its repercussion on root, periodontal ligament and alveolar bone tissues. The experimental group consisted of 72 Wistar rats divided in four subgroups: Naive, Saline and Zoledronic Acid groups at the conc...
Protective Effect of cashew gum (Anacardium occidentale L.) on 5-Fluorouracil-i...
Miranda, João Antônio Leal de; Barreto, João Erivan Façanha; Martins, Dainesy Santos; Pimentel, Paulo Vitor de Souza; Costa, Deiziane Viana da SilvaIntestinal mucositis is a common complication associated with 5-fluorouracil (5-FU), a chemotherapeutic agent used for cancer treatment. Cashew gum (CG) has been reported as a potent anti-inflammatory agent. In the present study, we aimed to evaluate the e ect of CG extracted from the exudate of Anacardium occidentale L. on experimental intestinal mucositis induced by 5-FU. Swiss mice were randomly divided into...
5-Fluorouracil induces enteric neuron death and glial activation during intesti...
Costa, Deiziane V. S.; Bon-Frauches, Ana C.; Silva, Angeline M. H. P.; Lima-Júnior, Roberto C. P.; Martins, Conceição S.5-Fluorouracil (5-FU) is an anticancer agent whose main side effects include intestinal mucositis associated with intestinal motility alterations maybe due to an effect on the enteric nervous system (ENS), but the underlying mechanism remains unclear. In this report, we used an animal model to investigate the participation of the S100B/RAGE/NFκB pathway in intestinal mucositis and enteric neurotoxicity caused b...
Transforming growth factor β1/SMAD signaling pathway activation protects the in...
Tinoco-Veras, Christianne Maria; Santos, Ana Angélica Q. A.; Stipursky, Joice; Meloni, Marcelo; Araujo, Ana Paula Bérgamo; Foschetti, Danielle AbreuClostridium difficile , the main cause of diarrhea in hospitalized patients, produces toxins A (TcdA) and B (TcdB), which affect intestinal epithelial cell survival, proliferation, and migration and induce an intense inflammatory response. Trans- forming growth factor (TGF- ) is a pleiotropic cytokine affecting enterocyte and immune/inflammatory responses. However, it has been shown that exposure of in- testina...
Effects of metformin on inflammation, oxidative stress, and bone loss in a rat ...
Araújo, Aurigena Antunes de; Pereira, Aline de Sousa Barbosa Freitas; Medeiros, Caroline Addison Carvalho Xavier de; Brito, Gerly Anne de CastroAim To evaluate the effects of metformin (Met) on inflammation, oxidative stress, and bone loss in a rat model of ligature-induced periodontitis. Materials & methods Male albino Wistar rats were divided randomly into five groups of twenty-one rats each, and given the following treatments for 10 days: (1) no ligature + water, (2) ligature + water, (3) ligature + 50 mg/kg Met, (4) ligature + 100 mg/kg Met, and (5...
Role of the route of leukotrienes in an experimental model of oral mucositis in...
Silva, Viviane Carvalho da; Leitão, Renata Ferreira de Carvalho; Brito, Gerly Anne de Castro; Martins, Conceição da Silva; Freire, Gildenio EstevamPurpose: To investigate the participation of cysteinyl leukotrienes in the pathophysiology of oral mucositis. Methods: Oral mucositis was induced in hamsters using 5-fluorouracil (5-FU; 60 and 40 mg/kg; i.p., on days 1 and 2, respectively, and with excoriations in jugal mucosa on day 4). Montelukast (10, 20, or 40 mg/kg/d; gavage), MK886 (3 mg/kg/d, i.p.), or saline or celecoxib (7.5 mg/kg/d; i.p.) was administ...
The involvement of mast cells in the irinotecan-induced enteric neurons loss an...
Nogueira, Ludmila T.; Costa, Deiziane V. S.; Gomes, Antoniella Souza; Martins, Conceição S.; Silva, Angeline M. H. P.; Coelho-Aguiar, Juliana M.Background The irinotecan (CPT-11) causes intestinal mucositis and diarrhea that may be related to changes in the enteric nervous system (ENS). In inflammatory condition, mast cells release a variety of pro-inflammatory mediators that can interact with the ENS cells. It has not been explored whether CPT-11 is able to alter the enteric glial and neuronal cell, and the role of mast cells in this effect. Therefore...
Topical HPMC/S-nitrosoglutathione solution decreases inflammation and bone reso...
Martins, Conceição S.; Leitão, Renata Ferreira de Carvalho; Melo, Iracema M.; Santos, Glaylton S. Santo; Baldim, Victor Baldim; Bonfim, Luana E.S-nitrosoglutathione (GSNO) is a nitric oxide (NO) donor, which exerts antioxidant, anti-inflammatory, and microbicidal actions. Intragingival application of GSNO was already shown to decrease alveolar bone loss, inflammation and oxidative stress in an experimental periodontal disease (EPD) model. In the present study, we evaluated the potential therapeutic effect of topical applications of hydroxypropylmethylc...