4 documents found, page 1 of 1
Attention-Deficit/Hyperactivity Disorder Animal Model Presents Retinal Alterati...
Sanches, Eliane S.; Boia, Raquel; Leitão, Ricardo A.; Madeira, Maria H.; Fontes-Ribeiro, Carlos A.; Ambrósio, António Francisco; Fernandes, RosaAttention-Deficit/Hyperactivity Disorder (ADHD) is one of the most prevalent neurodevelopmental disorders. Interestingly, children with ADHD seem to experience more ophthalmologic abnormalities, and the impact of methylphenidate (MPH) use on retinal physiology remains unclear. Thus, we aimed to unravel the retina's structural, functional, and cellular alterations and the impact of MPH in ADHD versus the control...
Effect of hypoproteic and high-fat diets on hippocampal blood-brain barrier per...
Aquino, Cristhyane Costa de; Leitão, Ricardo A.; Alves, Luis Antonio de Oliveira; Coelho-Santos, Vanessa; Guerrant, Richard L.; Ribeiro, Carlos F.Worldwide, millions of people are exposed to dietary imbalance that impacts in health and quality of life. In developing countries, like in Brazil, in poor settings, dietary habits, traditionally hypoproteic, are changing rapidly to western-type high-fat foods. These rapidly changing dietary habits are imposing new challenges to human health and there are many questions in the field that remain to be answered. ...
Effect of Hypoproteic and High-Fat Diets on Hippocampal Blood-Brain Barrier Per...
de Aquino, Cristhyane Costa; Leitão, Ricardo A.; Oliveira Alves, Luís A.; Coelho-Santos, Vanessa; Guerrant, Richard L.; Ribeiro, Carlos F. M.Worldwide, millions of people are exposed to dietary imbalance that impacts in health and quality of life. In developing countries, like in Brazil, in poor settings, dietary habits, traditionally hypoproteic, are changing rapidly to western-type high-fat foods. These rapidly changing dietary habits are imposing new challenges to human health and there are many questions in the field that remain to be answered. ...
Testing the excitation/inhibition imbalance hypothesis in a mouse model of the ...
Gonçalves, Joana; Violante, Inês R.; Sereno, José; Leitão, Ricardo A.; Cai, Ying; Abrunhosa, Antero; Silva, Ana Paula; Silva, Alcino J.Background: Excitation/inhibition (E/I) imbalance remains a widely discussed hypothesis in autism spectrum disorders (ASD). The presence of such an imbalance may potentially define a therapeutic target for the treatment of cognitive disabilities related to this pathology. Consequently, the study of monogenic disorders related to autism, such as neurofibromatosis type 1 (NF1), represents a promising approach to ...