5 documents found, page 1 of 1
Ensaio clínico fase III para avaliação da eficácia terapêutica de um medicament...
Leite, Ana Lourdes Almeida e SilvaThe phase III trial aims to compare the new treatment to the standard treatment available for the same medical condition. The analysis of the data obtained at this phase may lead to the registration and approval by the health authorities for the commercial use of the new drug or procedure. FSP1001. As a herbal remedy it is traditionally used as a sedative and anxiolytic. Several preclinical studies have been pe...
Determination of nimodipine in plasma by HPLC-MS/MS and pharmacokinetic applica...
Nascimento, Demétrius Fernandes do; Moraes Filho, Manoel Odorico de; Bezerra, Fernando Antônio Frota; Pontes, Andréa Vieira; Uchoa, Célia Regina AmaralTo develop and validate a rapid, specific and highly sensitive method to quantify nimodipine in human plasma using dibucaine as the internal standard (IS). The analyte and IS were extracted from plasma samples by liquid-liquid extraction using hexane-ethyl acetate (1:1 v/v). The chromatographic separation was performed on a Varian ® Polaris C18 analytical column (3 m m, 50 x 2.0 mm) and pre-column Securityguard...
Perfil farmacocinético da talidomida nas doses de 200mg e 400mg em voluntários ...
Leite, Ana Lourdes Almeida e SilvaFormulation of thalidomide 100mg tablet was evaluated for its bioavailability (Thalidomide, Fundação Ezequiel Dias - FUNED) in 24 healthy male volunteers. The study conducted was open, randomized, with two treatments, and with a two-period crossover design, during which the volunteers were administered 200mg or 400mg of thalidomide with a seven day washout period. Plasma was obtained over a 36h interval. The th...
Determination of nimodipine in plasma by HPLC-MS/MS and pharmacokinetic applica...
Nascimento, Demétrius Fernandes do; Moraes, Manoel Odorico de; Bezerra, Fernando Antônio Frota; Pontes, Andréa Vieira; Uchoa, Célia Regina AmaralTo develop and validate a rapid, specific and highly sensitive method to quantify nimodipine in human plasma using dibucaine as the internal standard (IS). The analyte and IS were extracted from plasma samples by liquid-liquid extraction using hexane-ethyl acetate (1:1 v/v). The chromatographic separation was performed on a Varian® Polaris C18 analytical column (3 μm, 50 x 2.0 mm) and pre-column Securitygu...
Accidentes de trabajo involucrando los ojos: evaluación de riesgos laborales co...
Almeida, Cristiana Brasil de; Pagliuca, Lorita Marlena Freitag; Leite, Ana Lourdes Almeida e SilvaObjetivou-se identificar trabalhadores de enfermagem que sofreram acidentes oculares e o tipo de acidente; descrever as providências tomadas e propor metodologias de Educação em Saúde. Estudo descritivo, exploratório, realizado em maternidade pública, de setembro de 2002 a janeiro de 2003. A coleta de dados ocorreu por meio de observação direta do ambiente e entrevista com os trabalhadores. Os sujeitos foram de...