4 documents found, page 1 of 1
Enteric neuronal damage, intramuscular denervation and smooth muscle phenotype ...
Campos, Camila França; Cangussú, Silvia Dantas; Duz, Ana Luiza Cassin; Cartelle, Christiane Teixeira; Noviello, Maria de Lourdes; Veloso, Vanja MariaWe developed a novel murine model of long-term infection with Trypanosoma cruzi with the aim to elucidate the pathogenesis of megacolon and the associated adaptive and neuromuscular intestinal disorders. Our intent was to produce a chronic stage of the disease since the early treatment should avoid 100% mortality of untreated animals at acute phase. Treatment allowed animals to be kept infected and alive in ord...
Interferon-γ induced nitric oxide mediates in vitro neuronal damage by Trypanos...
Leite, Camila Megale Almeida; Galvão, Lúcia Maria da Cunha; Afonso, Luís Carlos Crocco; Cunha, Fernando de Queiroz; Arantes, Rosa Maria EstevesNeuronal lesions and peripheral denervation in Chagas' disease are related to local inflammation; however, the pathogenic mechanisms of neuronal lesions in the heart and megavisceras are still unclear. We investigated the involvement of nitric oxide (NO) on neuronal lesion in co-cultures of neurons and macrophages. Trypanosoma cruzi-infected and interferon-γ (IFN-γ)-activated co-cultures of neurons and wildtype...
Virulence in murine model shows the existence of two distinct populations of Br...
Ferreira, Jaqueline Maria Siqueira; Drumond, Betânia Paiva; Guedes, Maria Isabel Maldonado Coelho; Xavier, Marcelo Antônio PascoalBrazilian Vaccinia virus had been isolated from sentinel mice, rodents and recently from humans, cows and calves during outbreaks on dairy farms in several rural areas in Brazil, leading to high economic and social impact. Some phylogenetic studies have demonstrated the existence of two different populations of Brazilian Vaccinia virus strains circulating in nature, but little is known about their biological ch...
Short-term therapy with simvastatin reduces inflammatory mediators and heart in...
Silva, Rafael Rodrigues; Bajracharya, Deena Shrestha; Leite, Camila Megale Almeida; Leite, Romulo; Bahia, Maria TerezinhaTrypanosoma cruzi infection induces progressive cardiac inflammation that leads to fibrosis and modifications in the heart architecture and functionality. Statins, such as 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase inhibitors, have been studied due to their pleiotropic roles in modulating the inflammatory response. Our goal was to evaluate the effects of simvastatin on the cardiac inflammatory pr...