2 documents found, page 1 of 1
Evidence for host epigenetic signatures arising from arbovirus infections: a sy...
Aguiar, Gabriella Pequeno Costa Gomes de; Leite, Claudio Manuel Gonçalves da Silva; Dias, Beatriz; Vasconcelos, Silvania Maria MendesBackground: Arbovirus infections have steadily become a major pandemic threat. This study aimed at investigating the existence of host epigenetic markers arising from the principal arboviruses infections impacting on human health. We set to systematically review all published evidence describing any epigenetic modifications associated with infections from arboviruses, including, but not limited to, microRNAs, D...
Efeitos comportamentais e neuroquímicos de inibidores da enzima dipeptidilpetid...
Leite, Claudio Manuel Gonçalves da SilvaDepression is a mood disorder of high prevalence in the general population which is characterized by hypothymia, anhedonia and low energy. Inhibitors of the enzyme dipeptidylpeptidase 4 (DPP4) are drugs used to treat type 2 diabetes mellitus (DM2) which also have effects on the central nervous system (CNS). Therefore, we carried out this study with the objective of evaluating the behavioral, antioxidant and ant...