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PAMAM dendrimers: blood-brain barrier transport and neuronal uptake after focal...

Santos, SD; Xavier, M; Leite, D; Moreira, D; Custódio, B; Torrado, M; Castro, R; Leiro, V; Rodrigues, J; Tomás, H; Pêgo, AP

Drug delivery to the central nervous system is restricted by the blood-brain barrier (BBB). However, with the onset of stroke, the BBB becomes leaky, providing a window of opportunity to passively target the brain. Here, cationic poly(amido amine) (PAMAM) dendrimers of different generations were functionalized with poly(ethylene glycol) (PEG) to reduce cytotoxicity and prolong blood circulation half-life, aimin...

Date: 2018   |   Origin: Repositório Aberto da Universidade do Porto
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Constrictive pericarditis: Insights from cardiac computed tomography

Ribeiro, S; Bettencourt, N; Van Zeller, P; Leite, D; Carvalho, M; Ribeiro, VG

Date: 2012   |   Origin: Repositório Científico do Hospital de Braga
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