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The mammalian peroxisomal membrane is permeable to both GSH and GSSG - Implicat...
Ferreira, Maria J.; Rodrigues, Tony A.; Pedrosa, Ana G.; Gales, Luís; Salvador, Armindo; Francisco, Tânia; Azevedo, Jorge E.Despite the large amounts of H2O2 generated in mammalian peroxisomes, cysteine residues of intraperoxisomal proteins are maintained in a reduced state. The biochemistry behind this phenomenon remains unexplored, and simple questions such as "is the peroxisomal membrane permeable to glutathione?" or "is there a thiol-disulfide oxidoreductase in the organelle matrix?" still have no answer. We used a cell-free in ...
Data: 2023
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Origem: Estudo Geral - Universidade de Coimbra