16 documents found, page 1 of 2
Prenylated flavonoid-enriched fraction from maclura tinctoria shows biological ...
Almeida, Ayla das Chagas; Rodrigues, Laís Azevedo; Paulino, Graziela dos Santos; Aguilar, Ananda Pereira; Almeida, Alisson AndradeBackground: The Atlantic Forest biome extends along the entire Brazilian coast and is home to approximately 20,000 plant species, many of which are endemic; it is considered one of the hotspot regions of the planet. Several of these species are sources of natural products with biological activities that are still unknown. In this study, we evaluated the antimicrobial activity of 90 extracts derived from native ...
A computational approach using bioinformatics to screening drug targets for Lei...
Leite, João Paulo Viana; Chávez-Fumagalli, Miguel Angel; Schneider, Mônica Santos; Lage, Daniela Pagliara; Tavares, Grasiele de Sousa VieiraThe development of new therapeutic strategies to treat patients for leishmaniasis has become a priority. The antileishmanial activity of the strychnobiflavone flavonoid was recently demonstrated against Leishmania amazonensis and Leishmania infantum amastigotes and promastigotes. The biological effect of this molecule was identified due to its capacity to interfere in the parasite mitochondrial membrane; howeve...
Extract of the bark of bathysa cuspidata attenuates the development of chemical...
Rosa, Damiana Diniz; Reis, Sandra Aparecida dos; Siqueira, Nathane Pais; Gonçalves, Reggiani Vilela; Machado, Alessandra Barbosa FerreiraThe aim of this study was to investigate the effect of the bark extract Bathysa cuspidata on chemically induced preneoplastic colorectal lesions in Wistar rats. Forty male rats were randomly divided into four groups (n = 10 each): saline (control group, oral administration of saline solution 0.9%); dimethylsulfoxide (DMSO, vehicle control), B200 (treated with 200 mg/kg bark extract of B. cuspidata), and B400 (t...
Bark extract of Bathysa cuspidata in the treatment of liver injury induced by c...
Gonçalves, Reggiani Vilela; Matta, Sérgio Luis Pinto da; Novaes, Rômulo Dias; Leite, João Paulo Viana; Peluzio, Maria do Carmo GouveiaThe aim of this study was to investigate the effect of bark extract Bathysa cuspidata (BCE) in the reconstitution of hepatic parenchyma and stroma after dysfunction induced by the CCl4. Liver lesions were induced by intraperitoneal administration of CCl4 (1 mL/kg) every 48 h for 12 days. The animals were treated with B. cuspidata extract (BCE) administered by gavage for another 12 days. Forty-nine rats were ran...
Antioxidant study indicative of antibacterial and antimutagenic activities of a...
Diaz, Marisa Alves Nogueira; Fietto, Luciano Gomes; Leite, João Paulo Viana; Gontijo, Douglas Costa; Gontijo, Pablo Costa; Brandão, Geraldo CélioEthnopharmacological relevance; Several plant species of Miconia genus are commonly used in Brazilian folk medicine as anti-inflammatory agents and for the treatment of infectious diseases. Infusions and extracts of Miconia species are also reported as analgesic, antimicrobial, antimalarial, antioxidant, anti-inflammatory, antinociceptive, antimutagenic, and antitumoral. To determine the phytochemical compositi...
The influence of planting and harvesting times on the total phenolic content an...
Brasileiro, Beatriz Gonçalves; Leite, João Paulo Viana; Casali, Vicente Wagner Dias; Pizziolo, Virgínia Ramos; Coelho, Olívia Gonçalves LeãoO objetivo deste estudo foi avaliar a influência das épocas de plantio e colheita no teor de polifenóis e capacidade antioxidante de Talinum triangulare cultivadas em duas estações do ano (inverno e verão) e coletadas 30 e 60 dias após plantio. A quantificação dos polifenóis foi realizada pelo método de Folin-Ciocalteu e a atividade antioxidante por DPPH. Níveis elevados de polifenóis foram obtidos na semeadura...
Strychnos pseudoquina and its purified compounds present an effective in vitro ...
Lage, Paula Sousa; Andrade, Pedro Henrique Rocha de; Lopes, Amanda de Santana; Fumagalli, Miguel Angel Chávez; Valadares, Diogo GarciaThe development of new and cost-effective alternative therapeutic strategies to treat leishmaniasis has become a high priority. In the present study, the antileishmanial activity of Strychnos pseudoquina St. Hil. was investigated and pure compounds that presented this biological effect were isolated. An ethyl acetate extract was prepared, and it proved to be effective against Leishmania amazonensis. A bioactivi...
Identification of phenolic compounds and biologically related activities from O...
Gontijo, Douglas Costa; Brandão, Geraldo Célio; Gontijo, Pablo Costa; Oliveira, Alaíde Braga de; Diaz, Marisa Alves Nogueira; Fietto, Luciano GomesOcotea odorifera (Vell.) Rohwer is popularly used as food and flavoring. The aim of this study was to determine the chemical composition of the aqueous extract from O. odorifera leaves and evaluate the correlation of their phytochemical composition and biological activities. The antioxidant effect was determined by DPPH radical scavenging, β-carotene-linoleic acid and lipid peroxidation assays; the antibacteria...
Colleters in Bathysa cuspidata (Rubiaceae): Development, ultrastructure and che...
Coelho, Victor Peçanha de Miranda; Leite, João Paulo Viana; Fietto, Luciano Gomes; Ventrella, Marília ContinThis paper describes the development of colleters of Bathysa cuspidata, Rubiaceae, considering anatomical, histochemical and ultrastructural aspects and going from first differentiation stages until senescence. Further, the chemical composition of the secretion is investigated. The samples were prepared according to the usual techniques for light microscopy and scanning and transmission electron microscopy. Ele...
Strychnos pseudoquina modulates the morphological reorganization of the scar ti...
Sarandy, Mariáurea Matias; Miranda, Lyvia Lopes; Altoé, Luciana Schulthais; Novaes, Rômulo Dias; Zanuncio, Virgínia Vinha; Leite, João Paulo VianaNatural substances are used in folk medicines to treat injuries. Strychnos pseudoquina has scarring, antipyretic, and antimalarial actions. The present study aimed to analyze the effect of S. pseudoquina on cutaneous wound healing in rats. The S. pseudoquina extract was submitted to phytochemical prospection. The levels of flavonoids and total phenolic compounds in the extract were 50.7 mg/g and 2.59 mg/g, resp...