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Delayed effects of tDCS combined with cognitive behavioral therapy in major dep...

Carvalho, Sandra; Gomes Coelho, Catarina; Leite, Jorge

Aims: This pilot study assessed the potential psychosocial and therapeutic impacts of augmenting transcranial direct current stimulation (tDCS) with cognitive behavioral therapy (CBT) in treatment-naïve patients diagnosed with major depressive disorder (MDD). Methods: In this double-blind randomized controlled trial, 10 subjects were randomized into two groups—CBT with active tDCS (active tDCS; n = 6; M = 33.3 ...


Beyond COVID-19 infection: cognitive and emotional pathways between posttraumat...

Vilaça, Margarida; Carvalho, Sandra; Leite, Jorge; Leite, Fernanda; Pereira, M. Graça

Background: Hospitalization during the COVID-19 pandemic has been linked with increased psychological distress, cognitive impairment, and reduced quality of life (QoL). Posttraumatic stress symptoms (PTSS) and rumination may significantly influence QoL outcomes, yet the mechanisms underlying these effects remain poorly understood. Based on the Cognitive Aging Model, this study examines the mediating effects of ...


Personalized language training and bi-hemispheric tDCS improve language connect...

Carvalho, Sandra; Mendes, Augusto J.; Pinto, José Miguel Soares Pereira; Sampaio, Adriana; Leite, Jorge

Background: Transcranial direct current stimulation (tDCS) has emerged as a promising neuromodulatory tool for language rehabilitation in chronic aphasia. However, the effects of bi-hemispheric, multisite stimulation remain largely unexplored, especially in people with chronic and treatment-resistant language impairments. The goal of this study is to look at the effects on behavior and brain activity of an indi...


Transcranial Direct Current Stimulation decreases P3 amplitude and inherent del...

Mendes, Augusto J.; Galdo-Álvarez, Santiago; Lema, Alberto; Carvalho, Sandra; Leite, Jorge

The inability to wait for a target before initiating an action (i.e., waiting impulsivity) is one of the main features of addictive behaviors. Current interventions for addiction, such as transcranial Direct Current Stimulation (tDCS), have been suggested to improve this inability. Nonetheless, the effects of tDCS on waiting impulsivity and underlying electrophysiological (EEG) markers are still not clear. Ther...


Transcranial direct current stimulation decreases P3 amplitude and inherent del...

Mendes, Augusto José; Galdo-Álvarez, Santiago; Calvo, Alberto Lema; Carvalho, Sandra; Leite, Jorge

The inability to wait for a target before initiating an action (i.e., waiting impulsivity) is one of the main features of addictive behaviors. Current interventions for addiction, such as transcranial Direct Current Stimulation (tDCS), have been suggested to improve this inability. Nonetheless, the effects of tDCS on waiting impulsivity and underlying electrophysiological (EEG) markers are still not clear. Ther...


Functional neuroimaging and behavioral correlates of multisite tDCS as an add-o...

Mendes, Augusto J.; Lema, Alberto; Soares, José Miguel; Sampaio, Adriana; Leite, Jorge; Carvalho, Sandra

Mary, who experienced non-fluent aphasia as a result of an ischemic stroke, received 10 years of personalized language training (LT), resulting in transient enhancements in speech and comprehension. To enhance these effects, multisite transcranial Direct Current Stimulation (tDCS) was added to her LT regimen for 15 sessions. Assessment using the Reliable Change Index showed that this combination improved her le...


Tailoring transcranial alternating current stimulation based on endogenous even...

Mendes, Augusto J.; Lema, Alberto; Carvalho, Sandra; Leite, Jorge

Background Transcranial alternating current stimulation (tACS) is a brain stimulation method for modulating ongoing endogenous oscillatory activity at specified frequency during sensory and cognitive processes. Given the overlap between event-related potentials (ERPs) and event-related oscillations (EROs), ERPs can be studied as putative biomarkers of the effects of tACS in the brain during cognitive/sensory ta...


Efficacy and safety of repetitive transcranial magnetic stimulation and transcr...

Mendes, Augusto J.; Leite, Jorge; Fernandes, Sara M.; Rodrigues, Pedro F. S.; Conde, Ana; Rocha, Magda

Repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS) are two of the most used non-pharmacological interventions for Alzheimer's Disease (AD). However, most of the clinical trials have focused on evaluating the effects on global cognition and not on specific cognitive functions. Therefore, considering that memory loss is one of the hallmark symptoms of AD, we aim...


Tailoring transcranial alternating current stimulation based on endogenous even...

Mendes, Augusto; Lema, Alberto; Carvalho, Sandra; Leite, Jorge

Background Transcranial alternating current stimulation (tACS) is a brain stimulation method for modulating ongoing endogenous oscillatory activity at specified frequency during sensory and cognitive processes. Given the overlap between event-related potentials (ERPs) and event-related oscillations (EROs), ERPs can be studied as putative biomarkers of the effects of tACS in the brain during cognitive/sensory ta...


Efficacy and safety of TMS and tDCS in memory deficits Alzheimer's disease

Mendes, Augusto J.; Rocha, Magda; Rodrigues, Pedro F. S.; Fernandes, Sara M.; Conde, Ana; Leite, Jorge

Transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) are promising non-pharmacological therapeutic options for Alzheimer’s´ Disease (AD). The aim of this meta-analysis is to assess which intervention (i.e., TMS or tDCS) is more effective for memory losses in people with AD. As secondary outcome, safety will be addressed. [...]


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