5 documents found, page 1 of 1
Genetic determinants of fungi-induced ROS production are associated with the ri...
Matzaraki, Vasiliki; Beno, Alexandra; Jaeger, Martin; Gresnigt, Mark S.; Keur, Nick; Boahen, Collins; Cunha, Cristina; Gonçalves, Samuel M.; Leite, Luis© 2022 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).; Reactive oxygen species (ROS) are an essential component of the host defense against fungal infections. However, little is known about how common genetic variation affects ROS-mediated antifungal host defense. In the present study, we investigated the genetic fact...
Genetic variation in PFKFB3 impairs antifungal immunometabolic responses and pr...
Gonçalves, Samuel M.; Antunes, Daniela; Leite, Luis; Mercier, Toine; Horst, Rob Ter; Vieira, Joana; Espada, Eduardo; Pinho Vaz, Carlos; Branca, RosaCopyright © 2021 Gonçalves et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.; Activation of immune cells in response to fungal infection involves the reprogramming of their cellular metabolism to support antimicrobial effector functions. Although metabolic pathways such as glycolysis are known to represent critical regulatory nodes i...
Phagosomal removal of fungal melanin reprograms macrophage metabolism to promot...
Gonçalves, Samuel M.; Duarte-Oliveira, Cláudio; Campos, Cláudia F.; Aimanianda, Vishukumar; ter Horst, Rob; Leite, Luis; Mercier, Toine© The Author(s) 2020. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party ...
IL-10 overexpression predisposes to invasive aspergillosis by suppressing antif...
Cunha, Cristina; Gonçalves, Samuel M.; Duarte-Oliveira, Claudio; Leite, Luis; Lagrou, Katrien; Marques, António; Lupianez, Carmen B.; Mesquita, Inês[Excerpt] To the Editor: Proinflammatory immune responses are critically required for antimicrobial host defenses; however, excessive inflammation has the potential to damage host tissues thereby paradoxically contributing to the progression of infection.[...]; Supported by the Northern Portugal Regional Operational Programme (NORTE 2020), under the Portugal 2020 Partnership Agreement, through the European Regi...
Avaliação de resíduos poliméricos pós-industriais e pós-consumo à base de polio...
Hubo, Sara; Ragaert, Kim; Leite, Luis; Martins, Carla I.Do ponto de vista económico, os polímeros reciclados são uma matéria-prima interessante para o uso em moldação por injeção. Estes são mais baratos do que os materiais virgens e a sua utilização contribui para o desenvolvimento de produtos sustentáveis. O presente estudo foca-se em poliolefinas obtidas por essa via. Geralmente distinguem-se os fluxos de materiais secundários de acordo com a sua origem, como pós-...