10 documents found, page 1 of 1
Barthel’s Index: A Better Predictor for COVID-19 Mortality Than Comorbidities
da Costa, JC; Manso, MC; Gregório, S; Leite, M; Pinto, JMBackground The most consistently identified mortality determinants for the new coronavirus 2019 (COVID-19) infection are aging, male sex, cardiovascular/respiratory diseases, and cancer. They were determined from heterogeneous cohorts that included patients with different disease severity and previous conditions. The main goal of this study was to determine if activities of daily living (ADL) dependence measure...
Shedding light on the african enigma: In vitro testing of homo sapiens-helicoba...
Cavadas, B; Leite, M; Pedro, N; Magalhães, AC; Melo, J; Correia, M; Máximo, V; Camacho, R; Fonseca, NA; Figueiredo, C; Pereira, LThe continuous characterization of genome-wide diversity in population and case- cohort samples, allied to the development of new algorithms, are shedding light on host ancestry impact and selection events on various infectious diseases. Especially interesting are the longstanding associations between humans and certain bacteria, such as the case of Helicobacter pylori, which could have been strong drivers of a...
Characterization of the striatal extracellular matrix in a mouse model of Parki...
Freitas, A; Aroso, M; Barros, A; Fernández, M; Conde-Sousa, E; Leite, M; Carvalho, ED; Ribeiro, CC; Ferreira, R; Pêgo, AP; Vitorino, R; Gomez-Lazaro, MParkinson’s disease’s etiology is unknown, although evidence suggests the involvement of oxidative modifications of intracellular components in disease pathobiology. Despite the known involvement of the extracellular matrix in physiology and disease, the influence of oxidative stress on the matrix has been neglected. The chemical modifications that might accumulate in matrix components due to their long half-li...
Isolation Method and Characterization of Outer Membranes Vesicles of Helicobact...
Melo, J; Pinto, V; Fernandes, T; Malheiro, AR; Osorio, H; Figueiredo, C; Leite, MOuter membrane vesicles (OMVs) are small vesicles constitutively shed by all Gram-negative bacterium, which have been proposed to play a role in Helicobacter pylori persistence and pathogenesis. The methods currently available for the isolation of H. pylori OMVs are diverse and time-consuming, raising the need for a protocol standardization, which was the main aim of this study. Here, we showed that the chemica...
Helicobacter pylori PqqE is a new virulence factor that cleaves junctional adhe...
Marques, MS; Costa, AC; Osorio, H; Pinto, ML; Relvas, S; Dinis-Ribeiro, M; Carneiro, F; Leite, M; Figueiredo, CHelicobacter pylori infects approximately half of the world’s population and is the strongest risk factor for peptic ulcer disease and gastric cancer, representing a major global health concern. H. pylori persistently colonizes the gastric epithelium, where it subverts the highly organized structures that maintain epithelial integrity. Here, a unique strategy used by H. pylori to disrupt the gastric epithelial ...
Musculoskeletal injuries and absenteeism among healthcare professionals-ICD-10 ...
Amaro, J; Magalhães, J; Leite, M; Aguiar, B; Ponte, P; Barrocas, J; Norton, PIntroduction Healthcare workers account for 10% of the EU’s total workforce, with a significant proportion of those employed in hospitals. Musculoskeletal injuries are the predominant group of injuries in healthcare professionals due to the physical demands of their work, such as the mobilization and positioning of the dependent patients. The management of this type of problem should take into account direct an...
Afadin downregulation by helicobacter pylori Induces epithelial to mesenchymal ...
Marques, MS; Melo, J; Cavadas, B; Mendes, N; Pereira, L; Carneiro, F; Figueiredo, C; Leite, MAfadin is a cytoplasmic protein of the adherens junctions, which regulates the formation and stabilization of both the adherens and the tight junctions. Aberrant expression of Afadin has been shown in cancer and its loss has been associated with epithelial-tomesenchymal transition (EMT). EMT is characterized by the change from an epithelial to a mesenchymal phenotype, with modifications on the expression of adh...
Síndrome Febril e Coma. Considerações a Propósito de Um Caso Clínico
Leite, M; Estrada, J; Ramos, J; Marques, A; Ventura, L; Vieira, JP; Trigo, C; Barata, DA endocardite infecciosa é relativamente pouco frequente na idade pediátrica, mas a sua morbilidade e mortalidade são elevadas. Os autores descrevem um caso clínico de endocardite infecciosa aguda por Staphylococcus aureus numa criança de 5 anos de idade, sem factores de risco conhecidos, diagnosticada na sequência de complicações neurológicas (degradação súbita do estado de consciência e sinais neurológicos fo...
Obstipação Funcional e Encopresis - Estudo Clínico e Manométrico
Santos, F; Leite, M; Cordeiro Ferreira, GA obstipação é um problema frequente na idade pediátrica. Os autores propuseram-se analisar os dados clínicos e os registos da manomatria anorectal de um grupo de crianças com obstipação funcional para encontrar as características preditivas de risco de desenvolvimento de encopresis. Foram analisados os processos de 46 crianças com características clínicas de obstipação funcional e agrupadas em dois grupos. o g...
Hereditary fructose intolerance.
Lopes, A I; Almeida, A G; Costa, A E; Costa, A; Leite, MHereditary fructose intolerance (HFI) is a rare autosomal recessive, metabolic disorder, that results from a deficiency of aldolase B (fructose-biphosphate aldolase) in the liver, kidney and intestine. Recent molecular studies have identified the mutation A149P in most European patients. We describe the first case of HFI with molecular analysis in a Portuguese child, presenting the same mutation of the aldolase...