Genomic surveillance of SARS-CoV-2 in Portugal was rapidly implemented by the National Institute of Health in the early stages of the COVID-19 epidemic, in collaboration with more than 50 laboratories distributed nationwide. Methods By applying recent phylodynamic models that allow integration of individual-based travel history, we reconstructed and characterized the spatio-temporal dynamics of SARSCoV-2 introd...
Genomic surveillance of SARS-CoV-2 was rapidly implemented in Portugal by the National Institute of Health in collaboration with a nationwide consortium of >50 hospitals/laboratories. Here, we track the geotemporal spread of a SARS-CoV-2 variant with a mutation (D839Y) in a potential host-interacting region involving the Spike fusion peptide, which is a target motif of anti-viral drugs that plays a key role in ...
Genomic surveillance of SARS-CoV-2 was rapidly implemented in Portugal by the National Institute of Health in collaboration with a nationwide consortium of >50 hospitals/laboratories. Here, we track the geo-temporal spread of a SARS-CoV-2 variant with a mutation (D839Y) in a potential host-interacting region involving the Spike fusion peptide, which is a target motif of anti-viral drugs that plays a key role in...
Outbreaks of protozoan agents such as Perkinsus olseni represent major losses for the shellfish producers, urging the development of measures to contain and decrease these episodes. Antimalarial drugs and selective inhibitors designed to target unique metabolic features of the parasite (metabolisms that are not replicated in the host, such as the folate, and shikimate pathways), have been successfully used in t...
The Cape Verde islands are part of the African Sahelian arid belt that possesses an erratic rain pattern prompting the need for water reservoirs, which are now critical for the country’s sustainability. Worldwide, freshwater cyanobacterial blooms are increasing in frequency due to global climate change and the eutrophication of water bodies, particularly in reservoirs. To date, there have been no risk assessmen...
Diatoms are photosynthetic microalgae, a group with a major environmental role on the planet due to the biogeochemical cycling of silica and global fixation of carbon. However, they can evolve into harmful blooms through a resourceful communication mechanism, not yet fully understood. Here, we demonstrate that a population of diatoms under darkness show quasi-periodic electrical oscillations, or intercellular w...
Neste trabalho foi avaliada a capacidade de remoção de querosene, de uma emulsão querosene/água, utilizando bagaço de caju quimicamente modificado. Primeiramente foi analisado o efeito do tratamento químico com hidróxido de sódio (NaOH) em diferentes concentrações, uma vez que o tratamento com álcali é capaz de desestruturar a lignina presente no bagaço, a qual dificulta o acesso aos sítios ativos do adsorvente...
É de fundamental importância o desenvolvimento de práticas de laboratório nos cursos de engenharia, porém os altos custos dos kits didáticos muitas vezes inviabilizam sua aquisição. No entanto, o presente trabalho teve como objetivo desenvolver um kit para aulas de cinética e reatores, utilizando materiais de fácil aquisição e com caráter ambiental, uma vez que o leito fixo é composto por bagaço de cana-de-açúc...
Transcriptional factor IIH (TFIIH) is involved in cell cycle regulation, nucleotide excision repair, and gene transcription. Mutations in three of its subunits, XPB, XPD, and TTDA, lead to human recessive genetic disorders such as trichothiodystrophy and xeroderma pigmentosum, the latter of which is sometimes associated with Cockayne's syndrome. In the present study, we investigate the sequence conservation of ...
A utilização de gordura animal para produção de sabão vem sendo cada vez mais enfatizada, devido ao fato deste apresentar um baixo custo. O sebo bovino é uma matéria-prima de grande relevância no Brasil, visto que, este é um subproduto da carne, que é produzida em larga escala no país. A adição de tensoativo a diferentes formulações apresenta comportamentos adversos quando se está analisando o processo de micel...