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The actin-binding protein α-adducin is required for maintaining axon diameter

Leite, SC; Sampaio, P; Sousa, VF; Nogueira-Rodrigues, J; Pinto-Costa, R; Peters, LL; Brites, P; Sousa, MM

The actin-binding protein adducin was recently identified as a component of the neuronal subcortical cytoskeleton. Here, we analyzed mice lacking adducin to uncover the function of this protein in actin rings. a-adducin knockout mice presented progressive axon enlargement in the spinal cord and optic and sciatic nerves, followed by axon degeneration and loss. Using stimulated emission depletion super-resolution...

Date: 2016   |   Origin: Repositório Aberto da Universidade do Porto
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