4 documents found, page 1 of 1
Retropharyngeal Lymph Node Metastases in Papillary Thyroid Carcinoma: A Case Se...
Pina, Henrique; Cavaco, Daniela; Nogueira, Ricardo; Leite, ValerianoIntroduction: The prevalence of retropharyngeal lymph node metastases in papillary thyroid carcinoma is low. The objective of this retrospective study was to assess our institutional experience with the management of such metastases and to compare results with other published series.Methods: We conducted a retrospective analysis of patients diagnosed with papillary thyroid carcinoma and retropharyngeal lymph no...
Surveillance of succinate dehydrogenase gene mutation carriers : insights from ...
Martins, Raquel; Cunha, Nuno; Simões, Helder; Matos, Maria João; Silva, João; Torres, Isabel; Rodrigues, Fernando; Leite, Valeriano; Teixeira, Manuel R.Objective: Mutations in the genes coding for succinate dehydrogenase (SDHx) are the most frequent germline alterations in pheochromocytomas and paragangliomas. Evidence for the advantages associated with presymptomatic screening for SDHx mutation carriers is scarce. This study describes a nationwide cohort of these mutation carriers and aims to compare patients with clinical manifestations of the disease and th...
TERT promoter mutations are a major indicator of poor outcome in differentiated...
Melo, Miguel; Gaspar Da Rocha, Adriana; Vinagre, João; Batista, Rui; Peixoto, Joana; Tavares, Catarina; Celestino, Ricardo; Almeida, AnaContext: Telomerase promoter mutations (TERT) were recently described in follicular cell-derived thyroid carcinomas (FCDTC) and seem to be more prevalent in aggressive cancers. Objectives: We aimed to evaluate the frequency of TERT promoter mutations in thyroid lesions and to investigate the prognostic significance of such mutations in a large cohort of patients with differentiated thyroid carcinomas (DTCs). De...
Chronic Hypocalcemia due to Anti-Calcium Sensing Receptor Antibodies
Marques, Pedro; Santos, Rita; Cavaco, Branca; Leite, ValerianoIntroduction: Hypoparathyroidism is an entity associated with hypocalcemia, more frequently a consequence of neck surgery. An autoimmune etiology is rare and its diagnosis difficult to establish.Clinical report: 52 year-old woman, with irrelevant past medical history and no significant familial conditions, referred because of hypocalcemia and basal ganglia calcifications, detected in the course of investigation...