6 documents found, page 1 of 1
Microcephaly measurement in adults and its association with clinical variables
Costa,Nicole Rezende da; Mancine,Livia; Salvini,Rogerio; Teixeira,Juliana de Melo; Rodriguez,Roberta Diehl; Leite,Renata Elaine ParaizoABSTRACT OBJECTIVE To establish a microcephaly cut-off size in adults using head circumference as an indirect measure of brain size, as well as to explore factors associated with microcephaly via data mining. METHODS In autopsy studies, head circumference was measured with an inelastic tape placed around the skull. Total brain volume was also directly measured. A linear regression was used to determine the asso...
Active lifestyle enhances protein expression profile in subjects with Lewy body...
Real,Caroline Cristiano; Suemoto,Cláudia Kimie; Binda,Karina Henrique; Grinberg,Lea Tenenholz; Pasqualucci,Carlos Augusto; Jacob Filho,WilsonABSTRACT. Clinical trials of the effects of physical activity have reported improvements in symptoms and quality of life in patients with Parkinson's disease (PD). Additionally, morphological brain changes after exercising were reported in PD animal models. However, these lifestyle-related changes were not evaluated in postmortem brain tissue. Objective: We aimed to evaluate, by immunohistochemistry, astrocytes...
Hypertension is the underlying cause of death assessed at the autopsy of indivi...
Coelho,Juliana Chaves; Ferretti-Rebustini,Renata Eloah de Lucena; Suemoto,Claudia Kimie; Leite,Renata Elaine Paraizo; Jacob-Filho,WilsonABSTRACT Objective: To analyze hypertension and its relationship with the causes of death identified by the autopsy. Method: Cross-sectional study analyzed 356 participants belonging to the Brazilian Aging Brain Study Group, over 50 years of age, autopsied at the Sao Paulo Autopsy Service between 2004 to 2014. A clinical interview was conducted with the informant of the deceased. Hypertension was defined by rep...
Association between diabetes and causes of dementia: Evidence from a clinicopat...
Matioli,Maria Niures Pimentel dos Santos; Suemoto,Claudia Kimie; Rodriguez,Roberta Diehl; Farias,Daniela Souza; Silva,Magnólia Moreira daABSTRACT. Background: Diabetes mellitus is a risk factor for dementia, especially for vascular dementia (VaD), but there is no consensus on diabetes as a risk factor for Alzheimer's disease (AD) and other causes of dementia. Objective: To explore the association between diabetes and the neuropathological etiology of dementia in a large autopsy study. Methods: Data were collected from the participants of the Bra...
Validity of the Katz Index to assess activities of daily living by informants i...
Ferretti-Rebustini,Renata Eloah de Lucena; Balbinotti,Marcos Alencar Abaide; Jacob-Filho,Wilson; Rebustini,Flávio; Suemoto,Claudia KimieAbstract OBJECTIVE To analyze the evidences of construct validity of the Katz Index for the retrospective assessment of activities of daily living (ADL) by informants, to assist neuropathological studies in the elderly. METHOD A cross-sectional study analyzed the functional ability of ADL measure by the Katz Index, of 650 cases randomly selected from the Brazilian Brain Bank of the Ageing Brain Study Group (BBB...
Association between cardiovascular disease and dementia
Suemoto,Claudia Kimie; Ferretti,Renata Eloah; Grinberg,Lea Tenenholz; Oliveira,Kátia Cristina de; Farfel,José Marcelo; Leite,Renata Elaine ParaizoAbstract Longitudinal studies have shown association between cardiovascular risk factors and dementia. However, these studies are not capable of detecting asymptomatic cardiovascular alterations and thus may provide erroneous estimates of association. Autopsy studies could be more useful in elucidating these questions. The present clinicopathological study sought to examine the relationship between dementia, ca...