6 documents found, page 1 of 1
Neuregulin-1 attenuates right ventricular diastolic stiffness in experimental p...
Adao, R; Mendes Ferreira, P; Maia Rocha, C; Santos Ribeiro, D; Rodrigues, PG; Vidal Meireles, A; Monteiro Pinto, C; Pimentel, LD; Falcao Pires, IWe have previously shown that treatment with recombinant human neuregulin-1 (rhNRG-1) improves pulmonary arterial hypertension (PAH) in a monocrotaline (MCT)-induced animal model, by decreasing pulmonary arterial remodelling and endothelial dysfunction, as well as by restoring right ventricular (RV) function. Additionally, rhNRG-1 treatment showed direct myocardial anti-remodelling effects in a model of pressur...
Update on pathophysiology and preventive strategies of anthracycline-induced ca...
Corremans, R; Adao, R; De Keulenaer, GW; Leite Moreira, AF; Brás-Silva CAnthracycline chemotherapy has a prominent role in treating many forms of cancer. Unfortunately, cardiotoxic side effects represent a serious limitation to their use, with doxorubicin being the leading drug of the group. Indeed, anthracycline-induced cardiomyopathy is an important public health concern because it may not be detected for many years and remains a lifelong threat. Even after decades of investigati...
Improvement in left intraventricular pressure gradients after aortic valve repl...
Guerra, M; Mendes Ferreira, P; Adao, R; Pereira, E; Vieira, M; Lourenco, AP; Brás-Silva C; Bastos, P; Vouga, L; Leite Moreira, AFNew Findings: What is the central question of this study? Normal diastolic and systolic intraventricular pressure gradients are decreased when left ventricular filling and/or emptying are compromised. We hypothesized that in patients with severe aortic valve stenosis, a condition that interferes with ventricular filling and emptying, those gradients would be disturbed. What is the main finding and its importanc...
Intraventricular Pressure Gradients in Heart Failure
Guerra, M; Bras Silva, C; Amorim, MJ; Moura, C; Bastos, P; Leite Moreira, AFThe aim of the present study was to characterize intraventricular pressure gradients (IVPGs) in an animal model of chronic heart failure. New Zealand rabbits were treated with doxorubicin (heart failure group, n=5) or saline (control group, n=5) and instrumented with pressure catheters placed in the apex and outflow-tract of left ventricle (LV) and with sonomicrometer crystals placed in the apex and base of the...
Rodent models of heart failure: an updated review
Gomes, AC; Falcao Pires, I; Pires, AL; Bras Silva, C; Leite Moreira, AFHeart failure (HF) is one of the major health and economic burdens worldwide, and its prevalence is continuously increasing. The study of HF requires reliable animal models to study the chronic changes and pharmacologic interventions in myocardial structure and function and to follow its progression toward HF. Indeed, during the past 40 years, basic and translational scientists have used small animal models to ...
Modulation of Myocardial Stiffness by beta-Adrenergic Stimulation Its Role in N...
Falcao Pires, I; Fontes Sousa, AP; Lopes Conceicao, L; Bras Silva, C; Leite Moreira, AFThe acute effects of ß-adrenergic stimulation on myocardial stiffness were evaluated. New-Zealand white rabbits were treated with saline (control group) or doxorubicin to induce heart failure (HF) (DOXO-HF group). Effects of isoprenaline (10 -10-1 -5 M), a non-selective ß-adrenergic agonist, were tested in papillary muscles from both groups. In the control group, the effects of isoprenaline were also evaluated ...