22 documents found, page 1 of 3

Medicina: ciência, educação e inovação ao “serviço da vida humana”

[Excerto] Escola, desde sempre, se apresentou como um espaço de liberdade e diversidade que fomenta a curiosidade e a produção de conhecimento, conferindo autonomia científica, técnica e profissional a todos os que nela se formam e diferenciam. Esta Escola representa, a todos os níveis, um marco inovador na formação médica, primando pela excelência, não só nos eixos de atividade tradicionais – pedagógico, cient...

Asymmetrical subcortical plasticity entails cognitive progression in older indi...

Structural brain asymmetries have been associated with cognition. However, it is not known to what extent neuropsychological parameters and structural laterality covary with aging. Seventy-five subjects drawn from a larger normal aging cohort were evaluated in terms of MRI and neuropsychological parameters at two moments (M1 and M2), 18 months apart. In this time frame, asymmetry as measured by structural later...

MORPhA Scale: behavioral and electroencephalographic validation of a rodent ane...

Background: Laboratory practice commonly implies rodent anesthesia. Such is instrumental not only for animal welfare, but also for standardized assessment of new anesthetics. New method: We developed and validated a grading system for a temporal follow-up of anesthesia. The Minho Objective Rodent Phenotypical Anesthesia (MORPhA) scale was tested in mice (C57BL/6 J) and rats (WistarHan) anesthetized with ketamin...

Evidence for lack of direct causality between pain and affective disturbances i...

Chronic pain is frequently accompanied by the manifestation of emotional disturbances and cognitive deficits. While a causality relation between pain and emotional/cognitive disturbances is generally assumed, several observations suggest a temporal dissociation and independent mechanisms. We therefore studied Sprague-Dawley rats that presented a natural resistance to pain manifestation in a neuropathy model (sp...

Righteousness (and lefteousness) of the old brain

Trait determinants of impulsive behavior: a comprehensive analysis of 188 rats

Impulsivity is a naturally occurring behavior that, when accentuated, can be found in a variety of neuropsychiatric disorders. The expression of trait impulsivity has been shown to change with a variety of factors, such as age and sex, but the existing literature does not reflect widespread consensus regarding the influence of modulating effects. We designed the present study to investigate, in a cohort of sign...

Functional Hemispheric (A)symmetries in the Aged Brain-Relevance for Working Me...

Functional hemispheric asymmetries have been described in different cognitive processes, such as decision-making and motivation. Variations in the pattern of left/right activity have been associated with normal brain functioning, and with neuropsychiatric diseases. Such asymmetries in brain activity evolve throughout life and are thought to decrease with aging, but clear associations with cognitive function hav...

Co-Transplantation of Adipose Tissue-Derived Stromal Cells and Olfactory Enshea...

Patients suffering from spinal cord injury (SCI) still have a dismal prognosis. Despite all the efforts developed in this area, currently there are no effective treatments. Therefore, cell therapies have been proposed as a viable alternative to the current treatments used. Adipose tissue-derived stromal cells (ASCs) and olfactory ensheathing cells (OECs) have been used with promising results in different models...

The nucleus reuniens: a key node in the neurocircuitry of stress and depression

The hippocampus and prefrontal cortex (PFC) are connected in a reciprocal manner: whereas the hippocampus projects directly to the PFC, a polysynaptic pathway that passes through the nucleus reuniens (RE) of the thalamus relays inputs from the PFC to the hippocampus. The present study demonstrates that lesioning and/or inactivation of the RE reduces coherence in the PFC-hippocampal pathway, provokes an antidepr...

Pawedness trait test (PaTRaT) : a new paradigm to evaluate paw preference and d...

In rodents, dexterity is commonly analyzed in preference paradigms in which animals are given the chance to use either the left or the right front paws to manipulate food. However, paw preference and dexterity at population and individual levels are controversial as results are incongruent across paradigms. We have therefore developed a semi-quantitative method-the pawdeness trait test (PaTRaT)-to evaluate paw ...