3 documents found, page 1 of 1
T-cell branched glycosylation as a mediator of colitis-associated colorectal ca...
Leite-Gomes, E; Silva, MC; Dias, AM; Fernandes, Â; Faria, G; Nogueira, R; Santos-Pereira, B; Fernandes-Mendes, H; Azevedo, CM; Raposo, J; Portero, JLBackground and Aims: Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract, established as a risk factor for colorectal cancer (CRC) development. Long-standing inflammation appears to play a central role in colitis-associated colorectal cancer (CAC). However, the molecular mechanism underlying CAC progression is still elusive. Previous evidence showed that levels of b...
A unique serum IgG glycosylation signature predicts development of Crohn’s dise...
Gaifem, J; Rodrigues, CS; Petralia, F; Alves, I; Leite-Gomes, E; Cavadas, B; Dias, AM; Moreira-Barbosa, C; Revés, J; Laird, RM; Novokmet, M; Štambuk, JInflammatory bowel disease (IBD) is characterized by chronic inflammation in the gut. There is growing evidence in Crohn’s disease (CD) of the existence of a preclinical period characterized by immunological changes preceding symptom onset that starts years before diagnosis. Gaining insight into this preclinical phase will allow disease prediction and prevention. Analysis of preclinical serum samples, up to 6 y...
Glycome dynamics in T and B cell development: basic immunological mechanisms an...
Vicente, MM; Leite-Gomes, E; Pinho, SSGlycans cover the surfaces of all mammalian cells through a process called glycosylation. Nearly all proteins and receptors that integrate the intricate series of co-stimulatory/inhibitory pathways of the immune system are glycosylated. Growing evidence indicates that the development of the immune system at the origins of T and B cell development is tightly regulated by glycosylation. In this opinion, we hypoth...