26 documents found, page 1 of 3

Long-term exposure to supraphysiological levels of testosterone impacts rat sub...

The salivary glands play a central role in the secretion of saliva, whose composition and volume affect oral and overall health. A lesser-explored dimension encompasses the possible changes in salivary gland proteomes in response to fluctuations in sex hormone levels. This study aimed to examine the effects of chronic exposure to testosterone on salivary gland remodeling, particularly focusing on proteomic adap...

Investigação Clínica da Iniciativa do Investigador em Portugal: Identificação d...

Association of thyroid function, within the euthyroid range, with cardiovascula...

Background: Thyroid hormones are important modulators of cardiovascular function. Both hypothyroidism and hyperthyroidism are known to contribute to an increased cardiovascular risk. It remains uncertain whether thyroid hormones level within the euthyroid range are associated with cardiometabolic risk. We aimed to evaluate the association between thyroid function levels within the euthyroid range and cardiovasc...

Thyroid Hormones within the Normal Range and Cardiac Function in the General Po...

Background: Hypothyroidism and hyperthyroidism are associated with marked changes in cardiac structure and function. However, the association of thyroid function within the normal range with cardiac structure and function in the general population remains uncertain. Methods: Eight hundred thirty-five subjects aged ≥45 years from the EPIPorto cohort (evaluation between 2006 and 2008) were cross-sectionally analy...

Pericardial NT-Pro-BNP and GDF-15 as Biomarkers of Atrial Fibrillation and Atri...

Aims: This study aimed to evaluate the association of GDF-15 and NT-pro-BNP in two different biological matrices with AF in severe aortic stenosis patients undergoing aortic valve replacement surgery (AVR), its association with atrial matrix remodeling, as well as with 30-day postoperative outcomes. Main Methods: One hundred and twenty-six patients between 2009 and 2019 with severe aortic stenosis undergoing AV...

Evaluation of thyroid function in patients hospitalized for acute heart failure

Background. Thyroid hormones (TH) are crucial for cardiovascular homeostasis. Recent evidence suggests that acute cardiovascular conditions, particularly acute heart failure (AHF), significantly impair the thyroid axis. Our aim was to evaluate the association of thyroid function with cardiovascular parameters and short-and long-term clinical outcomes in AHF patients. Methods. We performed a single-centre retros...

Frailty-Independent Undertreatment Negative Impact on Survival in Older Patient...

Purpose: The management of older adults with breast cancer (BC) remains controversial. The challenging assessment of aging idiosyncrasies and the scarce evidence of therapeutic guidelines can lead to undertreatment. Our goal was to measure undertreatment and assess its impact on survival. Methods: Consecutive patients with BC aged 70 years or older were prospectively enrolled in 2014. Three frailty screening to...

Atrial matrix remodeling in atrial fibrillation patients with aortic stenosis

Background. This study aimed to evaluate atrium extracellular matrix remodeling in atrial fibrillation (AF) patients with severe aortic stenosis, through histological fibrosis quantification and extracellular matrix gene expression analysis, as well as serum quantification of selected protein targets. Methods. A posthoc analysis of a prospective study was performed in a cohort of aortic stenosis patients. Betwe...

Metabolic syndrome severity score is associated with diastolic dysfunction and ...

Metabolic syndrome (MetS) affects approximately one out of three adults in western countries and it combines a cluster of cardiovascular risk factors. A continuous gender and race/ethnicity-specific MetS severity score was recently described and validated, and is an independent predictor of cardiovascular events, beyond individual MetS components. We aimed to assess if this score was associated with subclinical...

Lower Free Triiodothyronine Levels Within the Reference Range Are Associated wi...

Thyroid hormones play a central role in cardiovascular homeostasis. Lower free triiodothyronine (FT3) levels have been associated with worse prognosis in several conditions. However, contrary to thyrotropin (TSH) and free thyroxine (FT4), the role of FT3 in morbidity and mortality in the general population remains uncertain. Our objective was to evaluate the association between within the normal range FT3 level...