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Association between cognitive reserve proxies and frailty phenotype: data from ...
Lorenzo-López, L; Cibeira, N; Hemadeh, A; López-López, R; Lema-Arranz, C; Maseda, A; Fernández-Bertólez, N; Costa, S; Pásaro, E; Valdiglesias, VA potential protective role of cognitive reserve proxies against frailty has been suggested in older adults. We explored the cross-sectional association between cognitive reserve indicators and frailty phenotype. Data were obtained from the UK Biobank. We included 31,975 dementia-free participants aged ≥ 60 years (50.7% females, 2.2% frail) who completed a web-based cognitive assessment (fluid intelligence, wor...
Toxoplasma gondii IgG Serointensity Is Positively Associated With Frailty
Mohyuddin, H; Laffon, B; Teixeira, JP; Costa, S; Teixeira-Gomes, A; Pásaro, E; Constantine, N; Dagdag, A; Ortmeyer, HK; Tizenberg, B; Afram, L; Yen, PYBackground: Persistent inflammation related to aging (inflammaging) is exacerbated by chronic infections and contributes to frailty in older adults. We hypothesized associations between Toxoplasma gondii (T. gondii), a common parasite causing an oligosymptomatic unremitting infection, and frailty, and secondarily between T. gondii and previously reported markers of immune activation in frailty.Methods: We analy...
Relationship between DNA damage measured by the comet-assay and cognitive function
Lorenzo-López, L; Lema-Arranz, C; Fernández-Bertólez, N; Costa, S; Costa, C; Teixeira, JP; Pásaro, E; Valdiglesias, V; Laffon, BRecent studies exploring the relationship between DNA damage measured by the comet assay (single-cell gel electrophoresis) and cognitive function in both animal models and humans are reviewed and summarized. This manuscript provides an overview of studies exploring cognitive dysfunction related to DNA damage due to biological ageing process, cancer treatment, adverse environmental or occupational exposures, and...
Salivary Leucocytes as In Vitro Model to Evaluate Nanoparticle-Induced DNA Damage
Valdiglesias, V; Fernández-Bertólez, N; Lema-Arranz, C; Rodríguez-Fernández, R; Pásaro, E; Reis, AT; Teixeira, JP; Costa, C; Laffon, BMetal oxide nanoparticles (NPs) have a wide variety of applications in many consumer products and biomedical practices. As a result, human exposure to these nanomaterials is highly frequent, becoming an issue of concern to public health. Recently, human salivary leucocytes have been proposed as an adequate non-invasive alternative to peripheral blood leucocytes to evaluate genotoxicity in vitro. The present stu...