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Neuroprotective effects of platinum nanoparticle-based microreactors in bicucul...
Oliveira, Roberto N.; Carvalhinho-Lopes, Patrícia S.; Carvalho, Carolina P. F.; Hirata, Rafael Y. S.; Vaz, Sandra H.; Sebastião, Ana MEpilepsy designates a group of chronic brain disorders, characterized by the recurrence of hypersynchronous, repetitive activity, of neuronal clusters. Epileptic seizures are the hallmark of epilepsy. The primary goal of epilepsy treatment is to eliminate seizures with minimal side effects. Nevertheless, approximately 30% of patients do not respond to the available drugs. An imbalance between excitatory/inhibit...
Platinum nanoparticle-based microreactors protect against the behavioral and ne...
Hirata, Rafael Y. S.; Oliveira, Roberto N.; Silva, Mariana S. C. F.; Armada-Moreira, Adam; Vaz, Sandra H.; Ribeiro, Filipa; Sebastião, Ana MExcitotoxicity is described as the exacerbated activation of glutamate AMPA and NMDA receptors that leads to neuronal damage, and ultimately to cell death. Astrocytes are responsible for the clearance of 80-90% of synaptically released glutamate, preventing excitotoxicity. Chronic stress renders neurons vulnerable to excitotoxicity and has been associated to neuropsychiatric disorders, i.e., anxiety. Microreact...