A Leucemia Mielóide Crônica (LMC) é uma doença mieloproliferativa clonal caracterizada molecularmente pela formação da fusão gênica BCR-ABL. O mesilato de imatinib (MI), é o tratamento padrão da doença e foi o primeiro inibidor de tirosina-quinase a agir especificamente na oncoproteína BCR-ABL. No entanto, alguns casos de resistência a esta droga têm sido observados, o que faz necessário o uso de drogas mais po...
A antropometria é um método importante na avaliação do estado nutricional e possibilita traçar o perfil alimentar do indivíduo. Em crianças e adolescentes, o crescimento e o desenvolvimento são avaliados por meio dos indicadores: P/I, A/I, P/A e IMC/I. Esse trabalho teve como objetivo avaliar o estado nutricional e hematológico das crianças da EMEIEF Comissário Francisco Barbosa, Maracanaú – Ceará. Foram analis...
O Diabetes mellitus (DM) é uma doença metabólica de etiologia múltipla, caracterizada por uma hiperglicemia decorrente de uma alteração na secreção ou ação da insulina. O DM tipo 1 (DM1) está relacionado com a deficiência de insulina resultante da destruição das células-β do pâncreas; o DM tipo 2 (DM2) resulta de um processo fisiopatológico que culmina com a resistência à insulina, sendo o DM2 considerado um pr...
Multiple Myeloma (MM) is a hematological neoplasm characterized by bone marrow infiltration by clonal (malignant) plasma cells and the production of a monoclonal protein (MP). The disease remains incurable, although in recent years, with the advent of new treatments, progressive improvements in rates and duration of remission have been observed, resulting in a significant survival increment for affected patient...
Sickle cell anemia (SCA) is a genetic disease that causes important clinical manifestations due to chronic hemolysis and vascular occlusion. The aim of this study was to report a rare case of monozygotic twins diagnosed with SCA, presenting a different clinical characteristic. An interview with the patients was carried out and the medical records were consulted. One patient has a history of malleolar ulcer in t...
As plaquetas ou trombócitos são fragmentos celulares provenientes de megacariócitos na medula óssea. A avaliação da contagem de plaquetas e de outros parâmetros associados a mesma é importante na triagem de doenças hematológicas e não hematológicas. Em indivíduos normais existem entre 150 mil a 450 mil plaquetas por microlitro de sangue, sendo que seu tempo médio de vida é de dez dias. O objetivo deste estudo f...
Background. Sickle cell anaemia (SCA) is the most prevalentmonogenic disease in Brazil. In SCA, haemoglobin S (HbS) is formed, whichmodifies red blood cell morphology. Intravascular haemolysis occurs, in which free Hb and free radicals degrade nitric oxide (NO) and release arginase, which reduces arginine levels. Because arginine is a substrate for NO formation, this decrease leads to reduced NO (vasodilator) s...
Wernick’s Encephalopathy (WE) is an acute neuropsychiatric syndrome caused by thiamine deficiency post hematopoietic stem cell transplant (HSCT). WE is associated with high mortality and morbidity rates, but due to its rare occurrence, it is rarely considered in patients submitted to this procedure. Considering that, the manuscript reports the clinical characteristics and the possible factors that predisposed t...
Objective: Although hypothyroidism has been linked to oxidative stress, data regarding the relationship between thyroid hormone levels and oxidative stress is still inconsistent. This study was designed to evaluate the effect of levothyroxine replacement on oxidative stress in women with primary hypothyroidism. Design: A total of 25 female patients with primary hypothyroidism were included. Oxidative stress mar...
OBJECTIVES: To evaluate the effects of epoetin (EPO) alfa treatment on overall survival, event-free survival and response duration in patients with myelodysplastic syndrome (MDS) who were treated at a haematological referral centre in northeastern Brazil. METHODS: This was a retrospective cohort study of 36 patients diagnosed with MDS and treated with EPO alfa at 30,000 to 60,000 IU per week. Clinical data were...