8 documents found, page 1 of 1
Contemporary and historical human migration patterns shape hepatitis B virus di...
Potter, Barney I.; Thijssen, Marijn; Trovão, Nídia Sequeira; Pineda-Peña, Andrea; Reynders, Marijke; Mina, Thomas; Alvarez, CarolinaFunding Information: BIP and GB acknowledge support from the Internal Funds KU Leuven (Grant No. C14/18/094). GB acknowledges support from the Research Foundation—Flanders (‘Fonds voor Wetenschappelijk Onderzoek—Vlaanderen’, G0E1420N, G098321N). PL acknowledges support from the Research Foundation—Flanders (‘Fonds voor Wetenschappelijk Onderzoek—Vlaanderen’, G0D5117N, G0B9317N, G051322N). The opinions expressed...
Analyses of Early ZIKV Genomes Are Consistent with Viral Spread from Northeast ...
de Moraes, Laise; Portilho, Moyra M.; Vrancken, Bram; Van den Broeck, Frederik; Santos, Luciane Amorim; Cucco, Marina; Tauro, Laura B.; Kikuti, MarianaFunding Information: This research was funded by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior—Brasil (CAPES) [Finance Code 001 and 88881.130749/2016-01], Conselho Nacional de Desenvolvimento Científico e Tecnológico [439967/2016-3, 400830/2013-2, 440891/2016-7 and 311365/2021-3], Programa de Excelência em Pesquisa [420765/2017-4], Financiadora de Estudos e Projetos [MCTIC/FINEP/FNDCT 01/2016 ...
Reconstruction of the origin and dispersal of the worldwide dominant Hepatitis ...
Trovão, Nídia Sequeira; Thijssen, Marijn; Vrancken, Bram; Pineda-Peña, Andrea Clemencia; Mina, Thomas; Amini-Bavil-Olyaee, Samad; Lemey, PhilippeFunding Information: N.S.T. and P.L. were supported by the European Union Seventh Framework Programme [FP7/2007-2013] under Grant Agreement number 278433-PREDEMICS. The research leading to these results has received funding from the European Research Council under the European Union's Horizon 2020 research and innovation programme (grant agreement no. 725422 - ReservoirDOCS). MT is a PhD fellow at the Research ...
Earlier initiation of antiretroviral treatment coincides with an initial contro...
Vinken, Lore; Katrien, Fransen,; Cuypers, Lize; Alexiev, Ivailo; Balotta, Claudia; Laurent, Debaisieux,; Carole, Seguin-Devaux,; Sergio Garcìa, Ribas,Human immunodeficiency virus type 1 (HIV-1) non-B subtype infections occurred in Belgium since the 1980s, mainly amongst migrants and heterosexuals, whereas subtype B predominated in men-having-sex-with-men (MSM). In the last decade, the diagnosis of F1 sub-subtype in particular has increased substantially, which prompted us to perform a detailed reconstruction of its epidemiological history. To this purpose, t...
Quantifying next generation sequencing sample pre-processing bias in HIV-1 comp...
Vrancken, Bram; Trovão, Nídia Sequeira; Baele, Guy; Van Wijngaerden, Eric; Vandamme, Anne Mieke; van Laethem, Kristel; Lemey, PhilippeGenetic analyses play a central role in infectious disease research. Massively parallelized “mechanical cloning” and sequencing technologies were quickly adopted by HIV researchers in order to broaden the understanding of the clinical importance of minor drug-resistant variants. These efforts have, however, remained largely limited to small genomic regions. The growing need to monitor multiple genome regions fo...
An integrated map of HIV genome-wide variation from a population perspective
Li, Guangdi; Piampongsant, Supinya; Faria, Rodrigues N.; Voet, Arnout; Pineda-Peña, Andrea Clemencia; Khouri, Ricardo; Lemey, PhilippePMID: 25808207 WOS:000350853000001; Background: The HIV pandemic is characterized by extensive genetic variability, which has challenged the development of HIV drugs and vaccines. Although HIV genomes have been classified into different types, groups, subtypes and recombinants, a comprehensive study that maps HIV genome-wide diversity at the population level is still lacking to date. This study aims to characte...
Geographic and Temporal Trends in the Molecular Epidemiology and Genetic Mechan...
Rhee, Soo Yon; Blanco, Jose Luis; Jordan, Michael R.; Taylor, Jonathan; Lemey, Philippe; Varghese, Vici; Hamers, Raph L.; Bertagnolio, SilviaPMID: 25849352 WOS:000354825700001; Regional and subtype-specific mutational patterns of HIV-1 transmitted drug resistance (TDR) are essential for informing first-line antiretroviral (ARV) therapy guidelines and designing diagnostic assays for use in regions where standard genotypic resistance testing is not affordable. We sought to understand the molecular epidemiology of TDR and to identify the HIV-1 drug-res...
Phylogeography of dengue virus serotype 4, Brazil, 2010-2011.
Nunes, M. R. T.; Faria, Nuno Rodrigues; Vasconcelos, H.B.; Medeiros, D. B. A.; de Lima, C. P. S.; Carvalho, V. L.; da Silva, E. V. P.; Cardoso, J.F.Dengue virus serotype 4 (DENV-4) reemerged in Roraima State, Brazil, 28 years after it was last detected in the country in 1982. To study the origin and evolution of this reemergence, full-length sequences were obtained for 16 DENV-4 isolates from northern (Roraima, Amazonas, Pará States) and northeastern (Bahia State) Brazil during the 2010 and 2011 dengue virus seasons and for an isolate from the 1982 epidemi...