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APOBEC3 deaminase editing in mpox virus as evidence for sustained human transmi...

O’Toole, Áine; Neher, Richard A.; Ndodo, Nnaemeka; Borges, Vitor; Gannon, Ben; Gomes, João Paulo; Groves, Natalie; King, David J.; Maloney, Daniel

Historically, mpox has been characterized as an endemic zoonotic disease that transmits through contact with the reservoir rodent host in West and Central Africa. However, in May 2022, human cases of mpox were detected spreading internationally beyond countries with known endemic reservoirs. When the first cases from 2022 were sequenced, they shared 42 nucleotide differences from the closest mpox virus (MPXV) p...


Tracing the impact of public health interventions on HIV-1 transmission in Port...

Vasylyeva, Tetyana I.; Plessis, Louis du; Pineda-Peña, Andrea C.; Kühnert, Denise; Lemey, Philippe; Vandamme, Anne-Mieke; Gomes, Perpétua

Background Estimation of temporal changes in human immunodeficiency virus (HIV) transmission patterns can help to elucidate the impact of preventive strategies and public health policies. Methods Portuguese HIV-1 subtype B and G pol genetic sequences were appended to global reference data sets to identify country-specific transmission clades. Bayesian birth-death models were used to estimate subtype-specific ef...


Earlier initiation of antiretroviral treatment coincides with an initial contro...

Vinken, Lore; Fransen, Katrien; Cuypers, Lize; Alexiev, Ivailo; Balotta, Claudia; Debaisieux, Laurent; Seguin-Devaux, Carole; Ribas, Sergio García

Human immunodeficiency virus type 1 (HIV-1) non-B subtype infections occurred in Belgium since the 1980s, mainly amongst migrants and heterosexuals, whereas subtype B predominated in men-having-sex-with-men (MSM). In the last decade, the diagnosis of F1 sub-subtype in particular has increased substantially, which prompted us to perform a detailed reconstruction of its epidemiological history. To this purpose, t...


A novel hepatitis B virus species discovered in capuchin monkeys sheds new ligh...

Souza, Breno Frederico de Carvalho Dominguez; Konig, Alexander; Rasche, Andrea; Carneiro, Ianei de Oliveira; Stephan, Nora; Corman, Victor Max

University of Bonn Medical Centre. Institute of Virology. Bonn, Germany / Federal University of Bahia. University Hospital Prof. Edgard Santos. Infectious Diseases Research Laboratory. Salvador BA, Brazil.; Justus Liebig University. Institute of Medical Virology. National Reference Center for Hepatitis B and D Viruses. Giessen, Germany / German Centre for Infection Research. Germany.; University of Bonn Medical...

Date: 2018   |   Origin: Oasisbr

Air travel is associated with intracontinental spread of dengue virus serotypes...

Nunes, M?rcio Roberto Teixeira; Palacios, Gustavo; Faria, Nuno Rodrigues; Sousa Junior, Edivaldo Costa; Pantoja, Jamilla A; Rodrigues, Sueli Guerreiro

Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil.; United States Army Medical Research Institute for Infectious Diseases. Center for Genomic Sciences. Maryland, USA / Columbia University. Mailman School of Public Health. Center for Infection and Immunity. New York, USA.; University of Oxford. Department of Zoology. Oxford, United Kingdom.; Minist?rio da Sa...

Date: 2016   |   Origin: Oasisbr

Phylogeography of dengue virus serotype 4, Brazil, 2010-2011

Nunes, M?rcio Roberto Teixeira; Faria, Nuno Rodrigues; Vasconcelos, Helena Baldez; Medeiros, Daniele Barbosa de Almeida; Lima, Clayton Pereira Silva de

Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil.; Katholieke Universiteit Leuven. Leuven, Belgium.; Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil.; Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil.; Minist?rio da Sa?de. Secretaria de Vigil?nc...

Date: 2016   |   Origin: Oasisbr

On Hepatitis C Virus Evolution: The Interaction between Virus and Host towards ...

Bittar, Cíntia [UNESP]; Jardim, Ana Carolina Gomes [UNESP]; Yamasaki, Lilian Hiromi Tomonari [UNESP]; Carareto, Claudia Márcia Aparecida [UNESP]

Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-27T11:29:00Z No. of bitstreams: 0Bitstream added on 2014-05-27T14:32:27Z : No. of bitstreams: 1 2-s2.0-84876704094.pdf: 4134523 bytes, checksum: dad456ce5e1f1f14dd2697548494e930 (MD5); Made available in DSpace on 2014-05-27T11:29:00Z (GMT). No. of bitstreams: 0 Previous issue date: 2013-04-25; Background:Hepatitis C is a diseas...

Date: 2014   |   Origin: Oasisbr

Synonymous substitution rates predict HIV disease progression as a result of un...

Lemey, Philippe; Pond, Sergei L. Kosakovsky; Drummond, Alexei J.; Pybus, Oliver G.; Shapiro, Beth; Barroso, Helena; Taveira, Nuno; Rambaut, Andrew


Synonymous substitution rates predict HIV disease progression as a result of un...

Lemey, Philippe; Kosakovsky Pond, Sergei L.; Drummond, Alexei J.; Pybus, Oliver G.; Shapiro, Beth; Barroso, Helena; Taveira, Nuno; Rambaut, Andrew

Upon HIV transmission, some patients develop AIDS in only a few months, while others remain disease free for 20 or more years. This variation in the rate of disease progression is poorly understood and has been attributed to host genetics, host immune res


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