7 documents found, page 1 of 1
Development of Dl1.72, a Novel Anti-DLL1 Antibody with Anti-Tumor Efficacy agai...
Silva, G; Sales-Dias, J; Casal, D; Alves, S; Domenici, G; Barreto, C; Matos, C; Lemos, A; Matias, A; Kucheryava, K; Ferreira, A; Moita, MR; Braga, SThe Notch-signaling ligand DLL1 has emerged as an important player and promising therapeutic target in breast cancer (BC). DLL1-induced Notch activation promotes tumor cell proliferation, survival, migration, angiogenesis and BC stem cell maintenance. In BC, DLL1 overexpression is associated with poor prognosis, particularly in estrogen receptor-positive (ER+) subtypes. Directed therapy in early and advanced BC...
The reality of an Obesity Surgical Treatment Center in Portugal
Lopes, AR; Bernardo, J; Furtado, T; Sousa, C; Lemos, AIntroduction: Obesity surgery is used as the most effective treatment for morbid obesity, with better cost-benefit, less morbidity and mortality. The present study aimed to analyze the results of a surgical center for obesity treatment and integrate them with the most recent scientific evidence. Methods: Retrospective cross-sectional observational study involving 270 patients aged 18 years or older, who underwe...
Food Intake in Pregnant Women with Gestational Diabetes Mellitus
Lemos, A; Lopes, AR; Bernardo, J; Furtado, T; Sousa, CRationale: The aim of the present study was to verify the fulfillment of the nutritional requirements of macronutrients of pregnant women diagnosed with Gestational Diabetes Mellitus (GDM) at Lusíadas Lisboa Hospital. Inadequate glycemic control in GDM increases the risk of maternal, fetal and neonatal consequences, in this sense, nutritional therapy is essential during the follow-up of these pregnant women. Me...
Synthesis of a small library of nature-inspired xanthones and study of their an...
Resende, DISP; Pereira-Terra, P; Moreira, J; Freitas-Silva, J; Lemos, A; Gales, L; Pinto, E; Sousa, ME; Costa, PM; Pinto, MMMA series of thirteen xanthones 3-15 was prepared based on substitutional (appendage) diversity reactions. The series was structurally characterized based on their spectral data and HRMS, and the structures of xanthone derivatives 1, 7, and 8 were determined by single-crystal X-ray diffraction. This series, along with an in-house series of aminated xanthones 16-33, was tested for in-vitro antimicrobial activity ...
Care causing diagnosis, comorbidities and nutritional status of patients in con...
Marques, M; Gonçalves, V; Vieira, A; Magalhães, F; Godinho, J; Lemos, A; Costa, V; Faria, AnaIntroduction: Poor nutritional status has negative implications on prognosis, cost of care, morbidity and mortality. However, when nutritional assessment is not implemented, malnutrition can go untreated. Objectives: The aim of this study was to establish a relationship between care causing diagnosis, existing comorbidities and nutritional status of patients admitted to a long-term care unit. Methods: In the co...
Nutrition Day in nursing homes – risk factors for malnutrition
Marques, M; Damas, M; Costa, E; Brás, M; Lemos, A; Costa, V; Faria, AnaIntroduction: Malnutrition in institutionalized older adults has a significant prevalence, and is associated with cognitive decline, higher morbidity and mortality rates. Objectives: The aim of this study was to assess risk factors for malnutrition in nursing home residents. Methods: Through Nutrition Day audit (2016–2018), demographic and anthropometric data was collected, as well as medical history and nutrit...
Prevalence of cutaneous lesions in Freixo de Espada à Cinta.
Massa, A; Alves, R; Amado, J; Matos, E; Sanches, M; Selores, M; Santos, C; Costa, V; Velho, G; Oliveira, M; Ferreira, E; Taveira, M; Silva, N SIncidence or prevalence studies on cutaneous lesions in general populations are not available. The community observed by the authors (Freixo de Espada à Cinta, North-Eastern Portugal) is relatively closed. A pre-tested questionnaire for socio-demographic and clinical information was used and a physical observation was conducted in January and February 1994 by the Dermatology Team of Santo António General Hospit...