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shRNA-Based Screen Identifies Endocytic Recycling Pathway Components That Act a...
Gonçalves, Susana A; Macedo, Diana; Raquel, Helena; Simões, Pedro D; Giorgini, Flaviano; Ramalho, José S; Barral, Duarte C; Ferreira Moita, LuísAlpha-Synuclein (aSyn) misfolding and aggregation is common in several neurodegenerative diseases, including Parkinson's disease and dementia with Lewy bodies, which are known as synucleinopathies. Accumulating evidence suggests that secretion and cell-to-cell trafficking of pathological forms of aSyn may explain the typical patterns of disease progression. However, the molecular mechanisms controlling aSyn agg...
Date: 2016
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Origin: ARCA - Access to Research and Communication Annals