The adoption of blockchain technology by companies can change the way they interact with stakeholders, redefining communication strategies and other marketing processes. In this study, we investigated the relevance of blockchain applications for marketing management from the perspective of marketing-related professionals. Answers about blockchain technology application in the marketing arena were collected from...
The main goal of this article is to understand the potential learning applications based on AI technologies for health higher education students. We employed a Systematic Literature Review, contributing to explore to what extent AI technologies are currently influencing the Health learning processes in higher education and the skills developed during the learning path. The intent is to contribute to a more prof...
OBJECTIVES: Familial amyloid polyneuropathy (FAP ATTRV30M) shows a wide variation in age-at-onset (AO) between clusters, families, and among generations. We will now explore some candidate genes involved in altered disease pathways in order to assess their role as genetic modifiers of AO, using a family-centered approach. METHODS: We analyzed 62 tagging SNPs from nine genes-NGAL,MMP-9,BGN,MEK1,MEK2,ERK1,ERK2,HS...
In this work we describe the introduction of quantitative measures of emergent crowd patterns in an existing Agent-Based model (ABM) of street protests with multiple actors (police, protester and ‘media’ agents). The model was applied to a scenario of a police force defending a government building which protesters seek to invade. The improved model provided a coherent ‘narrative’ of the simulations and highligh...
Purpose: Evaluation of the impact of liver transplantation in the natural history of ocular disorders in familial amyloidotic polyneuropathy (FAP) amyloidosis TTR V30M related (ATTR V30M) patients. Design: A clinical, retrospective and cross-sectional study of 64 Portuguese FAP ATTR V30M patients was carried out between January 2005 and December 2011. Methods: Thirty-two liver transplanted patients (both eyes) ...
A infecção por Shigella no período neonatal é muito rara, sendo o diagnóstico frequentemente difícil pela diversidade e inespecificidade dos sintomas. Apresenta-se um caso de infecção por Shigella no período neonatal, que se apresentou com letargia, recusa alimentar e distensão abdominal, seguidos mais tarde de diarreia com sangue. Apesar de arrastada, teve boa evolução.
Descreve-se o caso de um recém-nascido com atraso de crescimento intra-uterino e microcefalia. cuja mãe tinha fenilcetonúria (PKU), não controlada durante a gravidez. Chama-se a atenção para o possível aparecimento de futuros casos, em fenilcetonúrias que tenham abandonado o tratamento dietético ou que tenham nascido antes do início do rastreio neonatal sistemático da PKU.
Epstein's Agent-Based model of civil violence has been very successful due to its simplicity and explanatory power, but does not represent important phenomena, such as processes operating at multiple scales and feedback mechanisms. In this work, we present an extension of Epstein's model that includes the effects of imprisonment delay, media coverage and feedback of rebellion bursts of the government's legitima...
Diabetes is associated with an increased risk for brain disorders, namely cognitive impairments associated with hippocampal dysfunction underlying diabetic encephalopathy. However, the impact of a prediabetic state on cognitive function is unknown. Therefore, we now investigated whether spatial learning and memory deficits and the underlying hippocampal dysfunction were already present in a prediabetic animal m...
Background: The high concordance rate of migraine in monozygotic twin pairs has long been recognised. In the current study, we present a monozygotic twin pair discordant for familial hemiplegic migraine (FHM). Case presentations: We evaluated 12 adult family members in 2012. The twin pair was separately examined by neurologists at different time points. Mutation screening was performed for known FHM-related gen...