2 documents found, page 1 of 1
Prostaglandin mediates IL-23/IL-17-induced neutrophil migration in inflammation...
Lemos, Henrique Paula; Grespan, Renata; Manfredo Vieira, Silvio; Cunha, Thiago Mattar; Verri, Waldiceu A.; Fernandes, Karla S.; Souto, Fabrício OliveiraIL-23/IL-17-induced neutrophil recruitment plays a pivotal role in rheumatoid arthritis (RA). However, the mechanism of the neutrophil recruitment is obscure. Here we report that prostaglandin enhances the IL-23/IL-17-induced neutrophil migration in a murine model of RA by inhibiting IL-12 and IFN γ production. Methylated BSA (mBSA) and IL-23-induced neutrophil migration was inhibited by anti-IL-23 and anti-IL-...
Joint NOD2/RIPK2 signaling regulates IL-17 axis and contributes to the developm...
Manfredo Vieira, Silvio; Cunha, Thiago Mattar; França, Rafael Freitas de Oliveira; Pinto, Larissa Garcia; Talbot, Jhimmy; Turato, Walter MiguelIntracellular pattern recognition receptors such as the nucleotide-binding oligomerization domain (NOD)-like receptors family members are key for innate immune recognition of microbial infection and may play important roles in the development of inflammatory diseases, including rheumatic diseases. In this study, we evaluated the role of NOD1 and NOD2 on development of experimental arthritis. Ag-induced arthriti...