11 documents found, page 1 of 2
Usability and Utility of a Mobile App to Deliver Health-Related Content to an O...
Lemos, M; Henriques, AR; Lopes, DG; Mendonça, N; Victorino, A; Costa, A; Arriaga, M; Gregório, Maria João; de Sousa, R; Canhão, H; Rodrigues, AM<jats:sec> <jats:title>Background</jats:title> <jats:p>Digital patient-centered interventions may be important tools for improving and promoting social interaction, health, and well-being among older adults. In this regard, we developed a mobile app called DigiAdherence for an older adult population, which consisted of easy-to-access short videos and messages, to improve health-related knowledge among them and ...
Screening a Targeted Panel of Genes by Next-Generation Sequencing Improves Risk...
Matos, S; Bernardo, P; Esteves, S; Botelho de Sousa, A; Lemos, M; Ribeiro, P; Silva, M; Nunes, A; Lobato, J; Frade, MJ; Gomes da Silva, M; Chacim, SAlthough mutation profiling of defined genes is recommended for classification of acute myeloid leukemia (AML) patients, screening of targeted gene panels using next-generation sequencing (NGS) is not always routinely used as standard of care. The objective of this study was to prospectively assess whether extended molecular monitoring using NGS adds clinical value for risk assessment in real-world AML patients...
A Common Variant in the CDK8 Gene Is Associated with Sporadic Pituitary Adenoma...
Gaspar, L; Gonçalves, C; Fonseca, F; Carvalho, D; Cortez, L; Palha, A; Barros, I; Nobre, E; Duarte, J; Amaral, C; Bugalho, MJ; Marques, O; Pereira, BThe majority of pituitary adenomas occur in a sporadic context, and in the absence of known genetic predisposition. Three common variants at the NEBL (rs2359536), PCDH15 (rs10763170) and CDK8 (rs17083838) loci were previously associated with sporadic pituitary adenomas in the Han Chinese population, but these findings have not yet been replicated in any other population. The aim of this case-control study was t...
A Video-Based Mobile App as a Health Literacy Tool for Older Adults Living at H...
Nunes-Da-Silva, C; Victorino, A; Lemos, M; Porojan, L; Costa, A; Arriaga, M; Gregório, Maria João; de Sousa, RD; Rodrigues, AM; Canhão, H<jats:sec> <jats:title>Background</jats:title> <jats:p>People aged 65 years are more likely to have health problems related to aging, polypharmacy, and low treatment adherence. Moreover, health literacy levels decrease with increasing age.</jats:p> </jats:sec> <jats:sec> <jats:title>Objective</jats:title> <jats:p>The aim of this study is to assess an apps utility in promoting health-related knowledge in people ...
Schistosomiasis and soil-transmitted helminthiasis preventive chemotherapy: Adv...
Lemos, M; Pedro, JM; Fançony, C; Moura, S; Brito, M; Nery, SV; Sousa, CP; Barros, HPreventive chemotherapy campaigns with praziquantel and albendazole are being implemented in Angola, as a high priority public health intervention. However, there are no published data regarding adverse events associated with these medications. In this context, we analysed adverse events due to co-administration of praziquantel and albendazole in endemic areas of schistosomiasis and soil-transmitted helminths i...
Integrated community-based intervention for urinary schistosomiasis and soil-tr...
Lemos, M; Fançony, C; Moura, S; Mirante, C; Sousa, P; Barros, H; Nery, S; Brito, MBackground: Schistosomiasis and soil-transmitted helminths (STH) infections are major public health problems. We aimed to study the 6-mo impact of mass drug administration with praziquantel and albendazole on urinary schistosomiasis and STH. Methods: We examined children (aged 2-15 y) from one hamlet, who provided urine and faeces samples at baseline (n=197), 1 mo (n=102) and 6 mo (n=92); 67 completed the proto...
A toggle-switch and a feed-forward loop engage in the control of the Drosophila...
Sánchez-Aragón, M; Cantisán-Gómez, J; Luque, C; Brás-Pereira, C; Lopes, CS; Lemos, M; Casares, FDipterans show a striking range of eye sizes, shapes, and functional specializations. Their eye is of the compound type, the most frequent eye architecture in nature. The development of this compound eye has been most studied in Drosophila melanogaster. The early development of the Drosophila eye is under the control of a gene regulatory network of transcription factors and signaling molecules called the retina...
A Novel BCR-ABL1 Mutation in a Patient with Philadelphia Chromosome-Positive B-...
Vinhas, R; Lourenço, A; Santos, S; Lemos, M; Ribeiro, P; Botelho de Sousa, A; Viana Baptista, P; Ramos Fernandes, APhiladelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) represents the most common genetic subtype of adult ALL (20%-30%) and accounts for approximately 50% of all cases in the elderly. It has been considered the subgroup of ALL with the worst outcome. The introduction of tyrosine kinase inhibitors (TKIs) allows complete hematologic remission virtually in all patients, with improved disease-free...
Síndrome Hemofagocítica: um Suspeito a Considerar
Souto Moura, T; Simões, I; Lemos, M; Azevedo, L; Gerivaz, R; Fonseca, PA síndrome hemofagocítica é uma entidade rara e potencialmente fatal, caracterizada por uma activação descontrolada do sistema imunitário, manifestando-se através de sintomas e sinais clínicos e laboratoriais de inflamação sistémica extrema. Pela inespecificidade dos mesmos, o seu diagnóstico requer um elevado grau de suspeição para implementação de terapêutica adequada e atempada. Os autores apresentam o caso ...
Novel FGFR1 Mutations in Kallmann Syndrome and Normosmic Idiopathic Hypogonadot...
Gonçalves, C; Bastos, M; Pignatelli, D; Borges, T; Aragüés, JM; Fonseca, F; Pereira, B; Socorro, S; Lemos, MOBJECTIVE: To determine the prevalence of fibroblast growth factor receptor 1 (FGFR1) mutations and their predicted functional consequences in patients with idiopathic hypogonadotropic hypogonadism (IHH). DESIGN: Cross-sectional study. SETTING: Multicentric. PATIENT(S): Fifty unrelated patients with IHH (21 with Kallmann syndrome and 29 with normosmic IHH). INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Patien...