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Sex differences in axial spondyloarthritis: data from a Portuguese spondyloarth...

Cunha, RN; Sousa, E; Khmelinskii, N; Ávila, P; Couto, M; Seixas, MI; Martins, N; Bernardes, M; Martins, A; da Silva, AB; Lourenço, MH; Miguel, C

Background: Axial spondyloarthritis (axSpA), particularly ankylosing spondylitis was historically considered a male’s disease and has been under-recognized in women. Emerging evidence reveals sex differences in pathophysiology, disease presentation and therapeutic efficacy. Objective: To identify differences between sexes in a Portuguese cohort of patients with axSpA regarding clinical manifestations, disease a...


Hidden musculoskeletal involvement in inflammatory bowel disease: a multicenter...

Rovisco, J; Duarte, C; Batticcioto, A; Sarzi-Puttini, P; Dragresshi, A; Portela, F; Gutierrez, M

BACKGROUND: Inflammatory bowel diseases are associated with a variety of extra-intestinal manifestations. The most frequent of these is joint involvement, which affects 16-33 % of IBD patients. Our aim was to evaluate the ultrasound prevalence of sub-clinical joint and entheseal involvement in patients with IBD without musculoskeletal symptoms, and to correlate the US findings with clinical and laboratory varia...


Paraneoplastic sclerodermiform syndrome--case report.

Rovisco, J; Serra, S; Abreu, P; Coutinho, M; Santiago, T; Inês, L; Pereira da Silva, JA

Occasionally, auto-immune diseases may emerge as paraneoplastic syndromes. This is especially recognized in the case of polymyositis/dermatomyostis, but it is an extremely rare event in systemic sclerosis (SSc). The authors report the case of a sixty-year-old woman who presented with Raynaud's phenomenon and rapidly progressing skin thickness of the forearms, hands and lower limbs. Patient evaluation revealed a...



A case of infliximab-induced lupus in a patient with ankylosing spondylitis: is...

Santiago, T; Santiago, MG; Rovisco, J; Duarte, C; Malcata, AB; Pereira da Silva, ja

Anti-TNF-α therapies are the latest class of medications found to be associated with drug-induced lupus, a distinctive entity known as anti-TNF-α-induced lupus (ATIL) (Williams et al., Rheumatology (Oxford) 48:716-20, 2009; De Rycke et al., Lupus 14:931-7, 2005; De Bandt et al., Clin Rheumatol 22:56-61, 2003). With the widespread use of these agents, it is likely that the incidence of ATIL will increase. The on...


Anticorps anti-Ku : prévalence et associations cliniques

Santiago, T; Santiago, M; Rovisco, J; Silva, N; Pereira da Silva, JA


Neuropatia Periférica e Leflunomida

Santiago, T; Rovisco, J; Silva, J; Malcata, AB


Brucelose osteo-articular: um retrato dos últimos 10 anos

Santiago, T; Rovisco, J; Silva, J; Pereira da Silva, JA

OBJECTIVES: Characterize Osteoarticular Brucellosis in the University Hospital of Coimbra (HUC) in the past decade. MATERIAL AND METHODS: A retrospective study of the cases diagnosed between January/2000 and December/2009 in the HUC. RESULTS: Ninety patients were admitted with the dia-gnosis of brucellosis in our hospital, of whom 44 (49%; 18 men; 26 women, mean 49.5 years) had osteoarticular complications. Twe...



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