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RUFY3 regulates endolysosomes perinuclear positioning, antigen presentation and...
Char, Rémy; Zhuangzhuang Liu; Jacqueline, Cédric; Davieau, Marion; Delgado, Maria-Graciela; Soufflet, Clara; Fallet, Mathieu; Chasson, LionelEndo-lysosomes transport along microtubules and clustering in the perinuclear area are two necessary steps for microbes to activate specialized phagocyte functions. We report that RUN and FYVE domain-containing protein 3 (RUFY3) exists as two alternative isoforms distinguishable by the presence of a C-terminal FYVE domain and by their affinity for phosphatidylinositol 3-phosphate on endosomal membranes. The FYV...
Endothelial cell invasion is controlled by dactylopodia
Figueiredo, Ana; Barbacena, Pedro; Russo, Ana; Vaccaro, Silvia; Ramalho, Daniela; Pena, Andreia; Lima, Aida Pires; Rua Ferreira, Rita; Fidalgo, MartaSprouting angiogenesis is fundamental for development and contributes to cancer, diabetic retinopathy, and cardiovascular diseases. Sprouting angiogenesis depends on the invasive properties of endothelial tip cells. However, there is very limited knowledge on how tip cells invade into tissues. Here, we show that endothelial tip cells use dactylopodia as the main cellular protrusion for invasion into nonvascular...